Dopamine receptor polymorphisms and drug response in schizophrenia

被引：13

作者：

Scharfetter, J ^{[1
]}

机构：

[1] Univ Klin Psychiat, Abt Allgemeine Psychiat, A-1090 Vienna, Austria

来源：

PHARMACOGENOMICS | 2001年 / 2卷 / 03期

关键词：

association; dopamine; pharmacogenetic; response; schizophrenia;

D O I：

10.1517/14622416.2.3.251

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The elucidation of the assumed genetic contribution to the predisposition towards schizophrenia is a scientifically challenging enterprise with considerable impact on therapeutic possibilities. A pharmacogenetic approach, targeted to the clinical response to medication, provides a promising alternative as a means of investigation, with the prospect of gaining knowledge about the disease and of developing an individually tailored medical treatment. This review will focus on dopamine receptor genes which have, due to the dopamine hypothesis of schizophrenia, been a prime target in pharmacogenetic studies of schizophrenia. The current status of the studies results will be displayed and future prospects will be discussed.

引用

页码：251 / 261

页数：11

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