Isonicotinamide self-association: the link between solvent and polymorph nucleation

被引：124
作者：
Kulkarni, Samir A. [1 ]
McGarrity, E. S. [1 ]
Meekes, Hugo [2 ]
ter Horst, Joop H. [1 ]
机构：
[1] Delft Univ Technol, Delft, Netherlands
[2] Radboud Univ Nijmegen, Inst Mol & Mat, NL-6525 AJ Nijmegen, Netherlands
来源：
CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 41期
关键词：
CRYSTAL POLYMORPHISM;
D O I：
10.1039/c2cc18025a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We show that, in a controlled and reproducible way, specific solvents lead to specific polymorphic forms of isonicotinamide. We argue on the basis of Raman and FTIR spectroscopy that the hydrogen bonding in solution kinetically drives the nucleation towards a specific form. This generally may lead to good understanding and control of polymorphism and crystal nucleation.
引用
收藏
页码：4983 / 4985
页数：3
相关论文
共 18 条
  • [1] Do polymorphic compounds make good cocrystallizing agents?: A structural case study that demonstrates the importance of synthon flexibility
    Aakeröy, CB
    Beatty, AM
    Helfrich, BA
    Nieuwenhuyzen, M
    [J]. CRYSTAL GROWTH & DESIGN, 2003, 3 (02) : 159 - 165
  • [2] An experimental and theoretical study of vibrational spectra of picolinamide, nicotinamide, and isonicotinamide
    Bakiler, Meric
    Bolukbasi, Olcay
    Yilmaz, Ayberk
    [J]. JOURNAL OF MOLECULAR STRUCTURE, 2007, 826 (01) : 6 - 16
  • [3] Bernstein J., 2020, Polymorphism in molecular crystals 2e, Vvol. 30
  • [4] Fourier transform infrared spectroscopy of 2′-deoxycytidine aggregates in CDCl3 solutions
    Biemann, Lars
    Haeber, Thomas
    Maydt, Daniela
    Schaper, Klaus
    Kleinermanns, Karl
    [J]. JOURNAL OF CHEMICAL PHYSICS, 2011, 134 (11)
  • [5] SAXS study of the nucleation of glycine crystals from a supersaturated solution
    Chattopadhyay, S
    Erdemir, D
    Evans, JMB
    Ilavsky, J
    Amenitsch, H
    Segre, CU
    Myerson, AS
    [J]. CRYSTAL GROWTH & DESIGN, 2005, 5 (02) : 523 - 527
  • [6] Crystal engineering - nucleation, the key step
    Davey, RJ
    Allen, K
    Blagden, N
    Cross, WI
    Lieberman, HF
    Quayle, MJ
    Righini, S
    Seton, L
    Tiddy, GJT
    [J]. CRYSTENGCOMM, 2002, 4 : 257 - 264
  • [7] Crystal polymorphism as a probe for molecular self-assembly during nucleation from solutions: The case of 2,6-dihydroxybenzoic acid
    Davey, RJ
    Blagden, N
    Righini, S
    Alison, H
    Quayle, MJ
    Fuller, S
    [J]. CRYSTAL GROWTH & DESIGN, 2001, 1 (01) : 59 - 65
  • [8] Expanding the crystal landscape of isonicotinamide: concomitant polymorphism and co-crystallisation
    Eccles, Kevin S.
    Deasy, Rebecca E.
    Fabian, Laszlo
    Braun, Doris E.
    Maguire, Anita R.
    Lawrence, Simon E.
    [J]. CRYSTENGCOMM, 2011, 13 (23): : 6923 - 6925
  • [9] Hydrogen bonding in ethyl carbamate studied by IR spectroscopy
    Furer, VL
    [J]. JOURNAL OF MOLECULAR STRUCTURE, 1998, 449 (01) : 53 - 59
  • [10] Kashchiev D, 2000, Nucleation
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