Isonicotinamide self-association: the link between solvent and polymorph nucleation

被引：124

作者：

Kulkarni, Samir A. ^{[1
]}

McGarrity, E. S. ^{[1
]}

Meekes, Hugo ^{[2
]}

ter Horst, Joop H. ^{[1
]}

机构：

[1] Delft Univ Technol, Delft, Netherlands

[2] Radboud Univ Nijmegen, Inst Mol & Mat, NL-6525 AJ Nijmegen, Netherlands

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 41期

关键词：

CRYSTAL POLYMORPHISM;

D O I：

10.1039/c2cc18025a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We show that, in a controlled and reproducible way, specific solvents lead to specific polymorphic forms of isonicotinamide. We argue on the basis of Raman and FTIR spectroscopy that the hydrogen bonding in solution kinetically drives the nucleation towards a specific form. This generally may lead to good understanding and control of polymorphism and crystal nucleation.

引用

收藏

页码：4983 / 4985

页数：3

相关论文

共 18 条

[1] Do polymorphic compounds make good cocrystallizing agents?: A structural case study that demonstrates the importance of synthon flexibility [J].

Aakeröy, CB ;

Beatty, AM ;

Helfrich, BA ;

Nieuwenhuyzen, M .

CRYSTAL GROWTH & DESIGN, 2003, 3 (02) :159-165

[2] An experimental and theoretical study of vibrational spectra of picolinamide, nicotinamide, and isonicotinamide [J].

Bakiler, Meric ;

Bolukbasi, Olcay ;

Yilmaz, Ayberk .

JOURNAL OF MOLECULAR STRUCTURE, 2007, 826 (01) :6-16

[3]

Bernstein J., 2020, Polymorphism in molecular crystals 2e, Vvol. 30

[4] Fourier transform infrared spectroscopy of 2′-deoxycytidine aggregates in CDCl3 solutions [J].

Biemann, Lars ;

Haeber, Thomas ;

Maydt, Daniela ;

Schaper, Klaus ;

Kleinermanns, Karl .

JOURNAL OF CHEMICAL PHYSICS, 2011, 134 (11)

[5] SAXS study of the nucleation of glycine crystals from a supersaturated solution [J].

Chattopadhyay, S ;

Erdemir, D ;

Evans, JMB ;

Ilavsky, J ;

Amenitsch, H ;

Segre, CU ;

Myerson, AS .

CRYSTAL GROWTH & DESIGN, 2005, 5 (02) :523-527

[6] Crystal engineering - nucleation, the key step [J].

Davey, RJ ;

Allen, K ;

Blagden, N ;

Cross, WI ;

Lieberman, HF ;

Quayle, MJ ;

Righini, S ;

Seton, L ;

Tiddy, GJT .

CRYSTENGCOMM, 2002, 4 :257-264

[7] Crystal polymorphism as a probe for molecular self-assembly during nucleation from solutions: The case of 2,6-dihydroxybenzoic acid [J].

Davey, RJ ;

Blagden, N ;

Righini, S ;

Alison, H ;

Quayle, MJ ;

Fuller, S .

CRYSTAL GROWTH & DESIGN, 2001, 1 (01) :59-65

[8] Expanding the crystal landscape of isonicotinamide: concomitant polymorphism and co-crystallisation [J].

Eccles, Kevin S. ;

Deasy, Rebecca E. ;

Fabian, Laszlo ;

Braun, Doris E. ;

Maguire, Anita R. ;

Lawrence, Simon E. .

CRYSTENGCOMM, 2011, 13 (23) :6923-6925

[9] Hydrogen bonding in ethyl carbamate studied by IR spectroscopy [J].

Furer, VL .

JOURNAL OF MOLECULAR STRUCTURE, 1998, 449 (01) :53-59

[10]

Kashchiev D, 2000, Nucleation