Phosphorylation of CARMA1:: The link(er) to NF-κB activation

被引：37
|
作者：
Rueda, D [1 ]
Thome, M [1 ]
机构：
[1] Univ Lausanne, Dept Biochem, BIL Biomed Res Ctr, CH-1066 Epalinges, Switzerland
来源：
IMMUNITY | 2005年 / 23卷 / 06期
关键词：
D O I：
10.1016/j.immuni.2005.11.007
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Antigen receptor-induced NF-KB activation depends on receptor-proximal and -distal signaling events. Two papers in this issue of Immunity demonstrate that PKC-dependent phosphorylation of CARMA1 is the critical molecular link that controls the activation of the IKK signalosome and NF-KB.
引用
收藏
页码：551 / 553
页数：3
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