Phosphorylation of CARMA1:: The link(er) to NF-κB activation

被引：37
|
作者：
Rueda, D [1 ]
Thome, M [1 ]
机构：
[1] Univ Lausanne, Dept Biochem, BIL Biomed Res Ctr, CH-1066 Epalinges, Switzerland
来源：
IMMUNITY | 2005年 / 23卷 / 06期
关键词：
D O I：
10.1016/j.immuni.2005.11.007
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Antigen receptor-induced NF-KB activation depends on receptor-proximal and -distal signaling events. Two papers in this issue of Immunity demonstrate that PKC-dependent phosphorylation of CARMA1 is the critical molecular link that controls the activation of the IKK signalosome and NF-KB.
引用
收藏
页码：551 / 553
页数：3
相关论文
共 50 条
  • [1] Phosphorylation of the CARMA1 linker controls NF-κB activation
    Sommer, K
    Guo, BC
    Pomerantz, JL
    Bandaranayake, AD
    Moreno-García, ME
    Ovechkina, YL
    Rawlings, DJ
    IMMUNITY, 2005, 23 (06) : 561 - 574
  • [2] Phosphorylation of CARMA1 by HPK1 is critical for NF-κB activation in T cells
    Brenner, Dirk
    Brechmann, Markus
    Roehling, Simone
    Tapernoux, Myriam
    Mock, Thomas
    Winter, Dominic
    Lehmann, Wolf D.
    Kiefer, Friedemann
    Thome, Margot
    Krammer, Peter H.
    Arnold, Ruediger
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (34) : 14508 - 14513
  • [3] A requirement for CARMA1 in TCR-induced NF-κB activation
    Donghai Wang
    Yun You
    Sara M. Case
    Linda M. McAllister-Lucas
    Lin Wang
    Peter S. DiStefano
    Gabriel Nuñez
    John Bertin
    Xin Lin
    Nature Immunology, 2002, 3 : 830 - 835
  • [4] A requirement for CARMA1 in TCR-induced NF-κB activation
    Wang, DH
    You, Y
    Case, SM
    McAllister-Lucas, LM
    Wang, L
    DiStefano, PS
    Nuñez, G
    Bertin, J
    Lin, X
    NATURE IMMUNOLOGY, 2002, 3 (09) : 830 - 835
  • [5] Phosphorylation of CARMA1 plays a critical role in T cell receptor-mediated NF-κB activation
    Matsumoto, R
    Wang, DH
    Blonska, M
    Li, HX
    Kobayashi, M
    Pappu, B
    Chen, YH
    Wang, DM
    Lin, X
    IMMUNITY, 2005, 23 (06) : 575 - 585
  • [6] CARMA1 is required for Akt-mediated NF-κB activation in T cells
    Narayan, P
    Holt, B
    Tosti, R
    Kane, LP
    MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (06) : 2327 - 2336
  • [7] Requirement for CARMA1 in antigen receptor-induced NF-κB activation and lymphocyte proliferation
    Egawa, T
    Albrecht, B
    Favier, B
    Sunshine, MJ
    Mirchandani, K
    O'Brien, W
    Thome, M
    Littman, DR
    CURRENT BIOLOGY, 2003, 13 (14) : 1252 - 1258
  • [8] CARMA1 is a critical lipid raft–associated regulator of TCR-induced NF-κB activation
    Olivier Gaide
    Benoît Favier
    Daniel F. Legler
    David Bonnet
    Brian Brissoni
    Salvatore Valitutti
    Claude Bron
    Jürg Tschopp
    Margot Thome
    Nature Immunology, 2002, 3 : 836 - 843
  • [9] Regulation of NF-κB activation in T cells via association of the adapter proteins ADAP and CARMA1
    Medeiros, Ricardo B.
    Burbach, Brandon J.
    Mueller, Kristen L.
    Srivastava, Rupa
    Moon, James J.
    Highfill, Sarah
    Peterson, Erik J.
    Shimizu, Yoji
    SCIENCE, 2007, 316 (5825) : 754 - 758
  • [10] CARMA1 coiled-coil domain is involved in the oligomerization and subcellular localization of CARMA1 and is required for T cell receptor-induced NF-κB activation
    Tanner, Matthew J.
    Hanel, Walter
    Gaffen, Sarah L.
    Lin, Xin
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (23) : 17141 - 17147
12345