Ruthenium-catalyzed reduction of N-alkoxy- and N-hydroxyamides

被引：16

作者：

Fukuzawa, Hiroko ^{[1
]}

Ura, Yasuyuki ^{[1
]}

Kataoka, Yasutaka ^{[1
]}

机构：

[1] Nara Womens Univ, Fac Sci, Dept Chem, Nara 6308506, Japan

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2011年 / 696卷 / 23期

关键词：

Reduction; Deprotection; N-Alkoxyamides; N-Hydroxyamides; Hydroxamic acids; Ruthenium; MATRIX-METALLOPROTEINASE INHIBITORS; DIELS-ALDER REACTIONS; HYDROXAMIC ACIDS; WEINREB AMIDES; O BONDS; ACRYLATE DIMERIZATION; ORGANIC-CHEMISTRY; COMPLEXES; CLEAVAGE; METHYLAMIDES;

D O I：

10.1016/j.jorganchem.2011.08.026

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A ruthenium-catalyzed reduction of N-alkoxy- and N-hydroxyamides was found to afford corresponding amides in good to high yields. A simple RuCl3/Zn-Cu/alcohol system, without the addition of any other ligands, exhibited a high catalytic activity, and therefore the present reaction does not require a stoichiometric amount of metals or metal complexes as reductants. When beta-substituted-alpha,beta-unsaturated N-methoxyamides were employed as substrates, concurrent hydrogenation of the olefin moiety proceeded slowly with deprotection of the methoxy group. In the reduction of N-hydroxyamides, the alcoholic solvent was found to function as a hydrogen donor. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：3643 / 3648

页数：6

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