A New Stimulation Mode for Deep Brain Stimulation in Parkinson's Disease: Theta Burst Stimulation

被引：23

作者：

Horn, Martin A. ^{[1
]}

Gulberti, Alessandro ^{[1
,2
]}

Guelke, Eileen ^{[1
]}

Buhmann, Carsten ^{[1
]}

Gerloff, Christian ^{[1
]}

Moll, Christian K. E. ^{[2
]}

Hamel, Wolfgang ^{[3
]}

Volkmann, Jens ^{[4
]}

Poetter-Nerger, Monika ^{[1
]}

机构：

[1] Univ Med Ctr Hamburg Eppendorf, Dept Neurol, Hamburg, Germany

[2] Univ Med Ctr Hamburg Eppendorf, Dept Neurophysiol & Pathophysiol, Hamburg, Germany

[3] Univ Med Ctr Hamburg Eppendorf, Dept Neurosurg, Hamburg, Germany

[4] Univ Hosp Wurzburg, Dept Neurol, Wurzburg, Germany

来源：

MOVEMENT DISORDERS | 2020年 / 35卷 / 08期

关键词：

deep brain stimulation; Parkinson's disease; subthalamic nucleus; therapeutic window width; theta burst stimulation; COORDINATED RESET;

D O I：

10.1002/mds.28083

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Objectives The purpose of this study was to assess efficacy and safety of a new patterned theta burst stimulation algorithm of DBS with the aim of expanding the therapeutic window and clinical benefit in PD. Methods In this single-center, randomized, double-blind, clinical short-term trial, unilateral conventional subthalamic DBS was compared with unilateral patterned stimulation algorithms with intraburst high- or low-frequency theta burst stimulation in 17 PD patients. Results There were no serious adverse events with theta burst stimulation. During monopolar review, conventional subthalamic DBS and high-frequency theta burst stimulation were comparable, but low-frequency theta burst stimulation differed by requiring higher stimulation amplitudes for symptom reduction, but a larger therapeutic window. High- and low-frequency theta burst stimulation with adapted stimulation amplitude were effective in PD symptom reduction with differential effects on akinesia and tremor, depending on the theta burst stimulation mode. Conclusions Theta burst stimulation is a safe and effective stimulation mode with potential future application opportunities. (c) 2020 International Parkinson and Movement Disorder Society

引用

页码：1471 / 1475

页数：5

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