Cerebral amyloid angiopathy in the elderly

被引：503

作者：

Viswanathan, Anand ^{[1
]}

Greenberg, Steven M.

机构：

[1] Massachusetts Gen Hosp, Hemorrhag Stroke Res Program, Stroke Serv, Dept Neurol, Boston, MA 02114 USA

来源：

ANNALS OF NEUROLOGY | 2011年 / 70卷 / 06期

关键词：

BLOOD-BRAIN-BARRIER; TRANSGENIC MOUSE MODEL; RECURRENT INTRACEREBRAL HEMORRHAGE; APOLIPOPROTEIN-E EPSILON-2; WHITE-MATTER LESIONS; ALZHEIMERS-DISEASE; BETA-PEPTIDE; CEREBROSPINAL-FLUID; A-BETA; CEREBROVASCULAR DYSFUNCTION;

D O I：

10.1002/ana.22516

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cerebral amyloid angiopathy (CAA) results from deposition of beta-amyloid in the media and adventitia of small arteries and capillaries of the leptomeninges and cerebral cortex and is a major cause of lobar intracerebral hemorrhage and cognitive impairment in the elderly. CAA is associated with a high prevalence of magnetic resonance imaging markers of small vessel disease, including cerebral microbleeds and white matter hyperintensities. Although advanced CAA is present in approximately 1/4 of brains with Alzheimer disease (AD), fewer than half of CAA cases meet pathologic criteria for AD. This review will discuss the pathophysiology of CAA and focus on new imaging modalities and laboratory biomarkers that may aid in the clinical diagnosis of individuals with the disease. ANN NEUROL 2011;70:871880

引用

页码：871 / 880

页数：10

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