Vitamin D and systemic lupus erythematosus - The hype and the hope

被引：56

作者：

Shoenfeld, Yehuda ^{[1
,2
,3
]}

Giacomelli, Roberto ^{[4
]}

Azrielant, Shir ^{[1
,2
]}

Berardicurti, Onorina ^{[4
]}

Reynolds, John A. ^{[5
]}

Bruce, Ian N. ^{[5
,6
]}

机构：

[1] Sheba Med Ctr, Zabludowicz Ctr Autoimmune Dis, IL-5265601 Ramat Gan, Israel

[2] Tel Aviv Univ, Sackler Fac Med, IL-6997801 Tel Aviv, Israel

[3] Tel Aviv Univ, Incumbent Laura Schwarz Kip Chair Res Autoimmune, IL-6997801 Tel Aviv, Israel

[4] Univ Aquila, Dept Biotechnol & Appl Clin Sci, Rheumatol Unit, Delta 6 Bldg, Laquila, Italy

[5] Univ Manchester, Fac Biol Med & Hlth, Ctr Musculoskeletal Res, Arthrit Res UK Ctr Epidemiol, Manchester, Lancs, England

[6] Cent Manchester Univ Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, NIHR Manchester Biomed Res Ctr, Manchester, Lancs, England

来源：

AUTOIMMUNITY REVIEWS | 2018年 / 17卷 / 01期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

Systemic lupus erythematosus; SLE; Vitamin D; Vitamin D deficiency; D DEFICIENCY; DISEASE-ACTIVITY; 25-HYDROXYVITAMIN D; D-RECEPTOR; CARDIOVASCULAR-DISEASE; RHEUMATIC-DISEASES; AUTOIMMUNE-DISEASE; RISK; EXPRESSION; ASSOCIATION;

D O I：

10.1016/j.autrev.2017.11.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Over the past 20 years, much has been written about the potential role of vitamin Din on adverse health outcomes. In recent years, evidence has accumulated regarding the effect of vitamin D on the immune system, and its different cells. Some studies have noted lower vitamin D concentrations in patients with SLE. These epidemiological data still not answer the question: is vitamin D deficiency the cause or the effect? To answer this, we will discuss the association between vitamin D deficiency and SLE and review the evidence from interventional studies. (C) 2017 Published by Elsevier B.V.

引用

页码：19 / 23

页数：5

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