Atorvastatin ameliorates experimental autoimmune neuritis by decreased Th1/Th17 cytokines and up-regulated T regulatory cells

被引:66
作者
Li, Xiao-Li [1 ]
Dou, Ying-Chun [2 ]
Liu, Ying [1 ]
Shi, Chang-Wen [3 ]
Cao, Li-Li [3 ]
Zhang, Xiu-Qing [1 ]
Zhu, Jie [4 ]
Duan, Rui-Sheng [1 ]
机构
[1] Shandong Univ, Shandong Prov Qianfoshan Hosp, Dept Neurol, Jinan 250014, Peoples R China
[2] Shandong Univ Tradit Chinese Med, Coll Basic Med Sci, Jinan 250014, Peoples R China
[3] Shandong Univ, Shandong Prov Qianfoshan Hosp, Cent Lab, Jinan 250014, Peoples R China
[4] Karolinska Inst, Dept Neurobiol Care Sci & Soc, SE-14186 Stockholm, Sweden
基金
中国国家自然科学基金;
关键词
Atorvastatin; Experimental autoimmune neuritis; IL-17; CD80; Treg cells; IL-17; LOVASTATIN; STATINS; SIMVASTATIN; MYOCARDITIS; MECHANISMS; EXPRESSION; PARALYSIS; BRAIN;
D O I
10.1016/j.cellimm.2011.08.015
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Statins have anti-inflammatory and immune-regulating properties. To investigate the effects of atorvastatin on experimental autoimmune neuritis (EAN), an animal model of Guillain-Barre syndrome (GBS), atorvastatin was administered to Lewis rats immunized with bovine peripheral myelin in complete Freund's adjuvant. We found that atorvastatin ameliorated the clinical symptoms of EAN, decreased the numbers of inflammatory cells as well as IFN-gamma(+) and IL-17(+) cells in sciatic nerves, decreased the CD80 expression and increased the number of CD25(+)Foxp3(+) cells in mononuclear cells (MNC), and decreased the levels of IFN-gamma in MNC culture supernatants. These data provide strong evidence that atorvastatin can act as an inhibitor in EAN by inhibiting the immune response of Th1 and Th17, decreasing the expression of co-stimulatory molecule, and up-regulating the number of T regulatory cells. These data demonstrated that statins could be used as a therapeutic strategy in human GBS in future. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码:455 / 461
页数:7
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