Neuro-Coagulopathy: Blood Coagulation Factors in Central Nervous System Diseases
被引:70
|
作者:
De Luca, Ciro
论文数: 0引用数: 0
h-index: 0
机构:
Univ Campania Luigi Vanvitelli, Lab Neuronal Networks, I-80138 Naples, ItalyUniv Campania Luigi Vanvitelli, Lab Neuronal Networks, I-80138 Naples, Italy
De Luca, Ciro
[1
]
Virtuoso, Assunta
论文数: 0引用数: 0
h-index: 0
机构:
Univ Campania Luigi Vanvitelli, Lab Neuronal Networks, I-80138 Naples, ItalyUniv Campania Luigi Vanvitelli, Lab Neuronal Networks, I-80138 Naples, Italy
Virtuoso, Assunta
[1
]
Maggio, Nicola
论文数: 0引用数: 0
h-index: 0
机构:
Chaim Sheba Med Ctr, Dept Neurol, IL-52621 Tel Hashomer, Israel
Tel Aviv Univ, Sackler Fac Med, Dept Neurol & Neurosurg, IL-6997801 Tel Aviv, Israel
Tel Aviv Univ, Sagol Sch Neurosci, IL-6997801 Tel Aviv, IsraelUniv Campania Luigi Vanvitelli, Lab Neuronal Networks, I-80138 Naples, Italy
Maggio, Nicola
[2
,3
,4
]
Papa, Michele
论文数: 0引用数: 0
h-index: 0
机构:
Univ Campania Luigi Vanvitelli, Lab Neuronal Networks, I-80138 Naples, Italy
Univ Milano Bicocca, Ctr Syst Biol, SYSBIO, I-20126 Milan, ItalyUniv Campania Luigi Vanvitelli, Lab Neuronal Networks, I-80138 Naples, Italy
Blood coagulation factors and other proteins, with modulatory effects or modulated by the coagulation cascade have been reported to affect the pathophysiology of the central nervous system (CNS). The protease-activated receptors (PARs) pathway can be considered the central hub of this regulatory network, mainly through thrombin or activated protein C (aPC). These proteins, in fact, showed peculiar properties, being able to interfere with synaptic homeostasis other than coagulation itself. These specific functions modulate neuronal networks, acting both on resident (neurons, astrocytes, and microglia) as well as circulating immune system cells and the extracellular matrix. The pleiotropy of these effects is produced through different receptors, expressed in various cell types, in a dose- and time-dependent pattern. We reviewed how these pathways may be involved in neurodegenerative diseases (amyotrophic lateral sclerosis, Alzheimer's and Parkinson's diseases), multiple sclerosis, ischemic stroke and post-ischemic epilepsy, CNS cancer, addiction, and mental health. These data open up a new path for the potential therapeutic use of the agonist/antagonist of these proteins in the management of several central nervous system diseases.
机构:
Chaim Sheba Med Ctr, Dept Neurol, IL-52621 Tel Hashomer, Israel
Chaim Sheba Med Ctr, Joseph Sagol Neurosci Ctr, IL-52621 Tel Hashomer, Israel
Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, IsraelChaim Sheba Med Ctr, Dept Neurol, IL-52621 Tel Hashomer, Israel
机构:
Fourth Mil Med Univ, Xijing Hosp, Dept Neurosurg, Xian 710032, Peoples R China
Fourth Mil Med Univ, Xijing Hosp, Inst Neurosurg, Peoples Liberat Army China PLA,PLAs Key Lab Crit C, Xian 710032, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Neurosurg, Xian 710032, Peoples R China
Zhang, Haofuzi
Dai, Shuhui
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Xijing Hosp, Dept Neurosurg, Xian 710032, Peoples R China
Fourth Mil Med Univ, Natl Translat Sci Ctr Mol Med, Xian 710032, Peoples R China
Fourth Mil Med Univ, Dept Cell Biol, Xian 710032, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Neurosurg, Xian 710032, Peoples R China
Dai, Shuhui
Yang, Yuefan
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Xijing Hosp, Dept Neurosurg, Xian 710032, Peoples R China
Fourth Mil Med Univ, Dept Biomed Engn, Xian 710032, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Neurosurg, Xian 710032, Peoples R China
Yang, Yuefan
Wei, Jialiang
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Xijing Hosp, Dept Neurosurg, Xian 710032, Peoples R China
Fourth Mil Med Univ, Dept Hlth Serv, Xian 710032, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Neurosurg, Xian 710032, Peoples R China
Wei, Jialiang
Li, Xin
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Xijing Hosp, Dept Anesthesiol, Xian 710032, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Neurosurg, Xian 710032, Peoples R China
Li, Xin
Luo, Peng
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Xijing Hosp, Dept Neurosurg, Xian 710032, Peoples R China
Fourth Mil Med Univ, Xijing Hosp, Inst Neurosurg, Peoples Liberat Army China PLA,PLAs Key Lab Crit C, Xian 710032, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Neurosurg, Xian 710032, Peoples R China
Luo, Peng
Jiang, Xiaofan
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Xijing Hosp, Dept Neurosurg, Xian 710032, Peoples R China
Fourth Mil Med Univ, Xijing Hosp, Inst Neurosurg, Peoples Liberat Army China PLA,PLAs Key Lab Crit C, Xian 710032, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Neurosurg, Xian 710032, Peoples R China