Healthy donor effect: its magnitude in health research among blood donors

被引:109
作者
Atsma, Femke [1 ]
Veldhuizen, Ingrid
Verbeek, Andre
de Kort, Wim
de Vegt, Femmie
机构
[1] Sanquin Res, Dept Donor Studies, NL-6501 BA Nijmegen, Netherlands
关键词
MYOCARDIAL-INFARCTION; HEART-DISEASE; BODY IRON; DONATION; RISK; COHORT; BIAS; MEN; REDUCTION; MORTALITY;
D O I
10.1111/j.1537-2995.2010.03055.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BACKGROUND: The healthy donor effect has been mentioned as a methodologic problem in blood donor health research. The aim of this study was to investigate different elements of the healthy donor effect. STUDY DESIGN AND METHODS: First, recent donors (<4 years registered as a donor) were compared with the general population. Second, active and lapsed donors were compared. Third, short-career donors (<14 donations) were compared with long-career donors (>37 donations). Various health and lifestyle indicators were used as outcome measures. RESULTS: Compared to the general population, recent donors had a better self-rated health (odds ratio [OR], 1.43; 95% confidence interval [CI], 1.27-1.61), visited the general practitioner (GP) less often (OR, 0.66; 95% CI, 0.60-0.72), and were less often treated by a specialist (OR, 0.83; 95% CI, 0.75-0.93). Recent donors also exhibited a healthier lifestyle compared to the general population. When examining active versus lapsed donors, similar results were found in favor of active donors. With respect to donation career, long-career donors were healthier than short-career donors, but effects were less strong; the ORs were 1.33 (95% CI, 1.15-1.54) for self-rated health, 0.85 (95% CI, 0.76-0.94) for GP visit, and 0.83 (95% CI, 0.68-1.00) for specialist treatment. When comparing long-and short-career donors on lifestyle indicators, there were barely any significant differences. CONCLUSIONS: The findings strongly point to the presence of a healthy donor effect when comparing donors with the general population and active versus lapsed donors. The healthy donor effect was less pronounced within active donors, when comparing long- and short-career donors. Therefore, health research should primarily be carried out within active donors.
引用
收藏
页码:1820 / 1828
页数:9
相关论文
共 29 条
  • [1] THE EVOLVING CONCEPT OF THE HEALTHY WORKER SURVIVOR EFFECT
    ARRIGHI, HM
    HERTZPICCIOTTO, I
    [J]. EPIDEMIOLOGY, 1994, 5 (02) : 189 - 196
  • [2] Ascherio A, 2001, CIRCULATION, V103, P52
  • [3] Cardiovascular and demographic characteristics in whole blood and plasma donors: results from the Donor InSight study
    Atsma, Femke
    Veldhuizen, Ingrid
    de Vegt, Femmie
    Doggen, Carine
    de Kort, Wim
    [J]. TRANSFUSION, 2011, 51 (02) : 412 - 420
  • [4] CARPENTER LM, 1987, BRIT J IND MED, V44, P289
  • [5] Checkoway H, 2004, PRECISION VALIDITY S, V2nd, P83
  • [6] The influence of study characteristics on the healthy worker effect: A multiple regression analysis
    Chen, R
    Seaton, A
    [J]. OCCUPATIONAL MEDICINE-OXFORD, 1996, 46 (05): : 345 - 350
  • [7] CHOI BCK, 1992, J OCCUP ENVIRON MED, V34, P979
  • [8] Donation frequency, iron loss, and risk of cancer among blood donors
    Edgren, Gustaf
    Reilly, Marie
    Hjalgrim, Henrik
    Tran, Trung Nam
    Rostgaard, Klaus
    Adami, Johanna
    Titlestad, Kjell
    Shanwell, Agneta
    Melbye, Mads
    Nyren, Olof
    [J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2008, 100 (08) : 572 - 579
  • [9] Improving health profile of blood donors as a consequence of transfusion safety efforts
    Edgren, Gustaf
    Tran, Trung Nam
    Hjalgrim, Henrik
    Rostgaard, Klaus
    Shanwell, Agneta
    Titlestad, Kjell
    Wikman, Agneta
    Norda, Rut
    Jersild, Casper
    Wideroff, Louise
    Gridley, Gloria
    Adami, Johanna
    Melbye, Mads
    Nyren, Olof
    Reilly, Marie
    [J]. TRANSFUSION, 2007, 47 (11) : 2017 - 2024
  • [10] Blood donation, body iron status and carotid intima-media thickness
    Engberink, Marielle F.
    Geleijnse, Johanna M.
    Durga, Jane
    Swinkels, Dorine W.
    de Kort, Wim L. A. M.
    Schouten, Evert G.
    Verhoef, Petra
    [J]. ATHEROSCLEROSIS, 2008, 196 (02) : 856 - 862