Chemoprevention of carcinogen-DNA binding: The relative role of different oxygenated substituents on 4-methylcoumarins in the inhibition of aflatoxin B-1-DNA binding in vitro

被引：28

作者：

Raj, HG

Gupta, S

Biswas, G

Singh, S

Singh, A

Jha, A

Bisht, KS

Sharma, SK

Jain, SC

Parmar, VS

机构：

[1] UNIV DELHI,DEPT BIOCHEM,VP CHEST INST,DELHI 110007,INDIA

[2] UNIV DELHI,DEPT CHEM,DELHI 110007,INDIA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1996年 / 4卷 / 12期

关键词：

D O I：

10.1016/S0968-0896(96)00227-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eighteen 4-methylcoumarins bearing methoxy/hydroxy/acetoxy functionalities have been reported to effectively inhibit the rat liver microsome-mediated aflatoxin B-1-DNA binding in vitro. The contribution of functionality on coumarin nucleus towards the inhibition of AFB(1)-DNA binding is in the order acetoxy>hydroxy>methoxy. The results illustrate the structure-activity relationship. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2225 / 2228

页数：4

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[1] DIETARY PESTICIDES (99.99-PERCENT ALL NATURAL) [J].