Circulating Tumour Cells, Circulating Tumour DNA and Circulating MicroRNA in Metastatic Breast Carcinoma - What is the Role of Liquid Biopsy in Breast Cancer?

被引：14

作者：

Polasik, Arkadius ^{[1
]}

Tzschaschel, Marie ^{[1
]}

Schochter, Fabienne ^{[1
]}

de Gregorio, Amelie ^{[1
]}

Friedl, Thomas W. P. ^{[1
]}

Rack, Brigitte ^{[1
]}

Hartkopf, Andreas ^{[2
]}

Fasching, Peter A. ^{[3
]}

Schneeweiss, Andreas ^{[4
]}

Mueller, Volkmar ^{[5
]}

Huober, Jens ^{[1
]}

Janni, Wolfgang ^{[1
]}

Fehm, Tanja ^{[6
]}

机构：

[1] Univ Klinikum Ulm, Klin Gynakol & Geburtshilfe, Ulm, Germany

[2] Univ Klinikum Tubingen, Klin Gynakol & Geburtshilfe, Tubingen, Germany

[3] Univ Klinikum Erlangen, Klin Gynakol & Geburtshilfe, Erlangen, Germany

[4] Univ Klinikum Heidelberg, Natl Ctr Tumorerkrankungen, Heidelberg, Germany

[5] Univ Klinikum Hamburg Eppendorf, Klin Gynakol & Geburtshilfe, Hamburg, Germany

[6] Heinrich Heine Univ Dusseldorf, Klin Gynakol & Geburtshilfe, Dusseldorf, Germany

来源：

GEBURTSHILFE UND FRAUENHEILKUNDE | 2017年 / 77卷 / 12期

关键词：

breast; Her-2/neu (human epidermal growth factor recptor); hormonal receptor; mammary gland tumor; metastasis; POOLED ANALYSIS; HER2; STATUS; ESTROGEN-RECEPTOR; PIK3CA MUTATIONS; ESR1; MUTATIONS; BONE-MARROW; RESISTANCE; DISEASE; MARKER; SITES;

D O I：

10.1055/s-0043-122884

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Dissemination of tumour cells and the development of solid metastases occurs via blood vessels and lymphatics. Circulating tumour cells (CTCs) and circulating tumour DNA (ctDNA) can be detected in venous blood in patients with early and metastatic breast cancer, and their prognostic relevance has been demonstrated on numerous occasions. Repeated testing for CTCs and ctDNA, or regular so-called "liquid biopsy", can be performed easily at any stage during the course of disease. Additional molecular analysis allows definition of tumour characteristics and heterogeneity that may be associated with treatment resistance. This in turn makes personalised, targeted treatments possible that may achieve both improved overall survival and quality of life.

引用

页码：1291 / 1298

页数：8

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