Ipilimumab: A Promising Immunotherapy for Melanoma

被引：0
作者：
Thumar, Jaykumar R. [1 ]
Kluger, Harriet M. [1 ]
机构：
[1] Yale Univ, Sch Med, Yale Canc Ctr, New Haven, CT 06511 USA
来源：
ONCOLOGY-NEW YORK | 2010年 / 24卷 / 14期
关键词：
LYMPHOCYTE-ASSOCIATED ANTIGEN-4; METASTATIC MELANOMA; TUMOR-REGRESSION; CTLA-4; BLOCKADE; PHASE-III; T-CELLS; ANTIBODY BLOCKADE; INTERFERON-ALPHA; CANCER; ANTI-CTLA-4;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Antibody-based targeting of the immune suppressor molecule cytotoxic T-lymphocyte antigen 4 (CTLA-4) with ipilimumab has been studied in metastatic melanoma in a number of clinical trials, including a recent phase III trial. This marks the first randomized clinical trial reporting an overall survival benefit using immune modulation in metastatic melanoma. Along with its therapeutic benefits, ipilimumab presents unique challenges to clinicians; these are related to the monitoring of treatment response and the management of drug-related toxicities. This drug is currently being investigated in various cancers, and its indications are likely to be expanded.
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页码：1280 / 1288
页数：9
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