Formation of HIV-1 envelope-hepatitis B core antigen hybrids with high affinity for CD4

被引：2
|
作者：
Patterson, LJ
Aberdeen, A
Kone, J
Haben, M
Raymond, M
Berkower, I
机构：
[1] NIH, Immunoregulat Lab, DVP, Off Vaccine Res & Review,Ctr Biol,US FDA, Bethesda, MD 20892 USA
[2] NCI, Basic Res Lab, Div Basic Sci, NIH, Bethesda, MD 20892 USA
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2001年 / 285卷 / 03期
关键词：
HIV vaccine; immunogenicity; gp120; particle assembly;
D O I：
10.1006/bbrc.2001.5227
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have identified an acceptor site on HIV gp120, where foreign protein sequences can be inserted while retaining the native conformation of gp120. The resulting hybrids showed dual antigenicity, normal glycosylation, and high affinity binding of the CD4 receptor. This site allows insertion of highly immunogenic proteins such as core antigen of hepatitis B virus. By combining the immunogenicity of the carrier protein with the antigenicity of gp120, these hybrids may lead to modified HIV-1 antigens with enhanced immunogenicity. (C) 2001 Academic Press.
引用
收藏
页码：639 / 643
页数：5
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