Genotype frequencies at codon 129 of the Prion Protein Gene in Brazil: implications in susceptibility to variant Creutzfeldt-Jakob disease compared to European and Asian populations

被引：3

作者：

de Paula, EV ^{[1
]}

Addas-Carvalho, M ^{[1
]}

Costa, DSP ^{[1
]}

Saad, STO ^{[1
]}

Gilli, SCO ^{[1
]}

机构：

[1] Univ Estadual Campinas, Haematol & Haemotherapy Ctr, BR-13083970 Campinas, SP, Brazil

来源：

EUROPEAN JOURNAL OF EPIDEMIOLOGY | 2005年 / 20卷 / 07期

关键词：

codon; 129; genotype frequencies; prion diseases; transfusion; vCJD;

D O I：

10.1007/s10654-005-7455-5

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

A polymorphism at codon 129 of the prion protein gene has been shown to confer genetic susceptibility to prion diseases, and to influence the epidemic course of variant Creutzfeldt--Jakob disease. We employed a PCR-endonuclease digestion-based assay to investigate this genetic trait in Brazil, and then compared our results to previously published data from several European and Asian countries.

引用

页码：593 / 595

页数：3

共 22 条

[1] Codon 129 prion protein genotype and sporadic Creutzfeldt-Jakob disease [J].

Alperovitch, A ;

Zerr, I ;

Pocchiari, M ;

Mitrova, E ;

Cuesta, JD ;

Hegyi, I ;

Collins, S ;

Kretzschmar, H ;

van Duijn, C ;

Will, RG .

LANCET, 1999, 353 (9165) :1673-1674

[2]

Altman DG, 1990, PRACTICAL STAT MED R

[3]

[Anonymous], 2000, 500 AN POV

[4] Recipients of blood or blood products "at vCJD risk" - We need to define their rights and responsibilities and those of others [J].

Bird, SM .

BMJ-BRITISH MEDICAL JOURNAL, 2004, 328 (7432) :118-119

[5]

Bratosiewicz J, 1999, FOLIA NEUROPATHOL, V37, P277

[6] IATROGENIC CREUTZFELDT-JAKOB-DISEASE - AN EXAMPLE OF THE INTERPLAY BETWEEN ANCIENT GENES AND MODERN MEDICINE [J].

BROWN, P ;

CERVENAKOVA, L ;

GOLDFARB, LG ;

MCCOMBIE, WR ;

RUBENSTEIN, R ;

WILL, RG ;

POCCHIARI, M ;

MARTINEZLAGE, JF ;

SCALICI, C ;

MASULLO, C ;

GRAUPERA, G ;

LIGAN, J ;

GAJDUSEK, DC .

NEUROLOGY, 1994, 44 (02) :291-293

[7] GENETIC PREDISPOSITION TO IATROGENIC CREUTZFELDT-JAKOB DISEASE [J].

COLLINGE, J ;

PALMER, MS ;

DRYDEN, AJ .

LANCET, 1991, 337 (8755) :1441-1442

[8] Polymorphism at codon 129 of the prion protein gene is not associated with sporadic AD [J].

Combarros, O ;

Sánchez-Guerra, M ;

Llorca, J ;

Alvarez-Arcaya, A ;

Berciano, J ;

Peña, N ;

Fernández-Viadero, C .

NEUROLOGY, 2000, 55 (04) :593-595

[9] Variant Creutzfeldt-Jakob disease [J].

Esther A. Croes ;

Cornelia M. van Duijn .

European Journal of Epidemiology, 2003, 18 (6) :473-477

[10] SIMILAR GENETIC SUSCEPTIBILITY IN IATROGENIC AND SPORADIC CREUTZFELDT-JAKOB-DISEASE [J].

DESLYS, JP ;

MARCE, D ;

DORMONT, D .

JOURNAL OF GENERAL VIROLOGY, 1994, 75 :23-27

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