Adaptations of glutamatergic synapses in the striatum contribute to recovery from cerebellar damage

被引：22
作者：
Centonze, Diego [1 ,2 ]
Rossi, Silvia [1 ,2 ]
De Bartolo, Paola [2 ,3 ]
De Chiara, Valentina [1 ,2 ]
Foti, Francesca [2 ,3 ]
Musella, Alessandra [1 ,2 ]
Mataluni, Giorgia [1 ,2 ]
Rossi, Stefano [4 ]
Bernardi, Giorgio [1 ,2 ]
Koch, Giacomo [1 ,2 ]
Petrosini, Laura [2 ,3 ]
机构：
[1] Univ Roma Tor Vergata, Dipartimento Neurosci, Rome, Italy
[2] Fdn Santa Lucia, CERC, Rome, Italy
[3] Univ Roma La Sapienza, Dipartimento Psicol, Rome, Italy
[4] Univ Roma La Sapienza, Dipartimento Meccan & Aeronaut, Rome, Italy
来源：
EUROPEAN JOURNAL OF NEUROSCIENCE | 2008年 / 27卷 / 08期
关键词：
cerebellar deficits; EPSC; glutamate transmission; rat; recovery of function;
D O I：
10.1111/j.1460-9568.2008.06182.x
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Recent findings proposed that the cerebellum and the striatum, key structures in motor control, are more interconnected than commonly believed, and that the cerebellum may influence striatal activity. In the present study, the possible changes of synaptic transmission in the striatum of hemicerebellectomized rats have been investigated. Neurophysiological recordings showed a significant facilitation of glutamate transmission in the contralateral striatum occurring early following hemicerebellectomy. This process of synaptic adaptation appears to be relevant for the compensation of cerebellar deficits. Accordingly, pharmacological blockade of glutamate N-methyl-D-aspartate (NMDA) receptors with MK-801 prevented the rearrangement of excitatory synapses in the striatum and interfered with the recovery from motor disturbances in rats with cerebellar lesions. Hemicerebellectomy also perturbed gamma-aminobutyric acid (GABA) transmission in contralateral but not ipsilateral striatum. The present findings advance the role of striatal excitatory transmission in the compensation of cerebellar deficits, providing support to the notion that adaptations of striatal function exert a role in the recovery of cerebellar symptoms.
引用
收藏
页码：2188 / 2196
页数：9
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