Cell-targeted platinum nanoparticles and nanoparticle clusters

被引：9

作者：

Papst, Stefanie ^{[1
]}

Brimble, Margaret A. ^{[1
,4
]}

Evans, Clive W. ^{[2
]}

Verdon, Daniel J. ^{[2
]}

Feisst, Vaughan ^{[2
]}

Dunbar, P. Rod ^{[2
,4
]}

Tilley, Richard D. ^{[3
]}

Williams, David E. ^{[1
]}

机构：

[1] Univ Auckland, Sch Chem Sci, MacDiarmid Inst Adv Mat & Nanotechnol, Auckland 1123, New Zealand

[2] Univ Auckland, Sch Biol Sci, Auckland 1123, New Zealand

[3] Victoria Univ Wellington, Sch Chem & Phys Sci, MacDiarmid Inst Adv Mat & Nanotechnol, Wellington, New Zealand

[4] Univ Auckland, Maurice Wilkins Ctr, Auckland 1123, New Zealand

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 23期

关键词：

BINDING;

D O I：

10.1039/c5ob00822k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we report the facile preparation of cell-targeted platinum nanoparticles (PtNPs), through the design of peptides that, as a single molecule added in small concentration during the synthesis, control the size of PtNP clusters during their growth, stabilise the PtNPs in aqueous suspension and enable the functionalisation of the PtNPs with a versatile range of cell-targeting ligands. Water-soluble PtNPs targeted respectively at blood group antigens and at integrin receptors are demonstrated.

引用

页码：6567 / 6572

页数：6

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