Microbial metabolism of α-mangostin isolated from Garcinia mangostana L.

被引：31

作者：

Arunrattiyakorn, Panarat ^{[1
]}

Suksamrarn, Sunit ^{[1
]}

Suwannasai, Nuttika ^{[2
]}

Kanzaki, Hiroshi ^{[3
]}

机构：

[1] Srinakharinwirot Univ, Fac Sci, Dept Chem, Bangkok 10110, Thailand

[2] Srinakharinwirot Univ, Fac Sci, Dept Biol, Bangkok 10110, Thailand

[3] Okayama Univ, Grad Sch Nat Sci & Technol, Okayama 7008530, Japan

来源：

PHYTOCHEMISTRY | 2011年 / 72卷 / 08期

关键词：

Microbial metabolism; alpha-Mangostin; Sulfation; Anti-mycobacterial activity; PRENYLATED XANTHONES; FUNGAL METABOLISM; FRUIT;

D O I：

10.1016/j.phytochem.2011.02.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

alpha-Mangostin (1), a prenylated xanthone isolated from the fruit hull of Garcinia mangostana L., was individually metabolized by two fungi, Colletotrichum gloeosporioides (EYL131) and Neosartorya spathulata (EYR042), repectively. Incubation of 1 with C. gloeosporioides (EYL131) gave four metabolites which were identified as mangostin 3-sulfate (2), mangostanin 6-sulfate (3), 17,18-dihydroxymangostanin 6-sulfate (4)and isomangostanin 3-sulfate (5). Compound 2 was also formed by incubation with N. spathulata (EYR042). The structures of the isolated compounds were elucidated by spectroscopic data analysis. Of the isolated metabolites, 2 exhibited significant anti-mycobacterial activity against Mycobacterium tuberculosis. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：730 / 734

页数：5

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