Hemostatic cotton based on biocompatible poly(vinyl alcohol)/soluble starch-fish skin collagen composites

被引：13

作者：

Guo, Jiayi ^{[1
]}

Liu, Qun ^{[2
]}

Cheng, Jun ^{[2
]}

Fu, Xin ^{[1
]}

Zhang, Yucang ^{[2
]}

Yang, Huan ^{[3
]}

机构：

[1] Hainan Univ, Sch Chem Engn & Technol, Minist Educ, Key Lab Adv Mat Trop Isl Resources, Haikou 570228, Hainan, Peoples R China

[2] Jimei Univ, Coll Ocean Food & Biol Engn, Xiamen 361021, Fujian, Peoples R China

[3] Hainan Univ, Sch Mat Sci & Engn, Haikou 570228, Hainan, Peoples R China

来源：

MATERIALS TODAY COMMUNICATIONS | 2022年 / 32卷

基金：

中国国家自然科学基金;

关键词：

3-D porous structure; Water absorption ratio; Wound dressing; Rapid hemostatic; CROSS-LINKING; SPONGE; ANTIBACTERIAL; HEMORRHAGE; HYDROGEL;

D O I：

10.1016/j.mtcomm.2022.103812

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Fish skin collagen has attracted a wide range of attention in the field of hemostatic materials due to its excellent biocompatibility and hemostatic performance. In this work, the hemostatic cotton based on poly(vinyl alcohol)/ soluble starch-fish skin collagen (PVA/SS-FSC) composites was prepared by solvent displacement followed by lyophilization. The experimental results showed that the PVA/SS enabled the composite material to have 3-D porous structures. When compounding with FSC, PVA/SS-FSC(1) composite cotton (mass ratio 1:1:1) possessed 3-D porous structures, good water absorption, and no cytotoxicity or hemolytic properties. In vitro and in vivo experiments demonstrated that the PVA/SS-FSC(1) hemostatic cotton accelerated the coagulation rate, reduced blood loss, and improved the hemostatic efficiency. Furthermore, arterial hemostasis tests in rats confirmed that the PVA/SS-FSC(1) hemostatic cotton afforded a shorter hemostasis time (64 +/- 7 s) and lower blood loss (323 +/- 38 mg) compared with commercial hemostatic gauze (210 +/- 12 s and 840 +/- 41 mg, respectively), thus indicating promising applications in rapid wound hemostasis.

引用

页数：10

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