Genetic factors influencing alcohol dependence

被引：133
作者：
Mayfield, R. D. [1 ]
Harris, R. A. [1 ]
Schuckit, M. A. [2 ]
机构：
[1] Univ Texas Austin, Waggoner Ctr Alcohol & Addict Res, Austin, TX 78712 USA
[2] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 2008年 / 154卷 / 02期
关键词：
alcohol; alcoholism; alcohol dependence; endophenotype; genetic; gene expression; gene mapping; genome; microarray; linkage;
D O I：
10.1038/bjp.2008.88
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Plentiful data from both animal and human studies support the importance of genetic influences in substance abuse and dependence (Bierut et al., 1998; Tsuang et al., 1998; Kendler et al., 2003). This review summarizes the evidence supporting such genetic influences, places them into perspective regarding animal and human studies, discusses the importance of both genes and environment, and highlights some specific genes of interest regarding the vulnerabilities for problems associated with alcohol use disorders. A long history of repetitive heavy use of alcohol exists across generations as well as the high prevalence of alcohol-related problems in Western societies. Moreover, the information offered here addresses the importance of more general issues regarding genetics and gene expression related to alcohol abuse and dependence.
引用
收藏
页码：275 / 287
页数：13
相关论文
共 146 条
  • [1] Anni H, 2002, ALCOHOL RES HEALTH, V26, P219
  • [2] A cluster of differentially expressed signal transduction genes identified by microarray analysis in a rat genetic model of alcoholism
    Arlinde, C
    Sommer, W
    Bjork, K
    Reimers, M
    Hyytiä, P
    Kiianmaa, K
    Heilig, M
    [J]. PHARMACOGENOMICS JOURNAL, 2004, 4 (03) : 208 - 218
  • [3] Aschner M, 2002, BRAIN PATHOL, V12, P475
  • [4] Methodological considerations for gene expression profiling of human brain
    Atz, Mary
    Walsh, David
    Cartagena, Preston
    Li, Jun
    Evans, Simon
    Choudary, Prabhakara
    Overman, Kevin
    Stein, Richard
    Tomita, Hiro
    Potkin, Steven
    Myers, Rick
    Watson, Stanley J.
    Jones, E. G.
    Akil, Huda
    Bunney, William E., Jr.
    Vawter, Marquis P.
    [J]. JOURNAL OF NEUROSCIENCE METHODS, 2007, 163 (02) : 295 - 309
  • [5] Serotonin transporter gene variation is associated with alcohol sensitivity in rhesus macaques exposed to early-life stress
    Barr, CS
    Newman, TK
    Becker, ML
    Champoux, M
    Lesch, KP
    Suomi, SJ
    Goldman, D
    Higley, JD
    [J]. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2003, 27 (05) : 812 - 817
  • [6] The replicability of QTLs for murine alcohol preference drinking behavior across eight independent studies
    Belknap, JK
    Atkins, AL
    [J]. MAMMALIAN GENOME, 2001, 12 (12) : 893 - 899
  • [7] Quantitative trait locus mapping for acute functional tolerance to ethanol in the L x S recombinant inbred panel
    Bennett, Beth
    Downing, Chris
    Carosone-Link, Phyllis
    Ponicsan, Heather
    Ruf, Cathy
    Johnson, Thomas E.
    [J]. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2007, 31 (02) : 200 - 208
  • [8] Mouse genetic models in alcohol research
    Bennett, Beth
    Downing, Chris
    Parker, Clarissa
    Johnson, Thomas E.
    [J]. TRENDS IN GENETICS, 2006, 22 (07) : 367 - 374
  • [9] Chromosomal loci influencing chronic alcohol withdrawal severity
    Bergeson, SE
    Warren, RK
    Crabbe, JC
    Metten, P
    Erwin, VG
    Belknap, JK
    [J]. MAMMALIAN GENOME, 2003, 14 (07) : 454 - 463
  • [10] Familial transmission of substance dependence: Alcohol, marijuana, cocaine, and habitual smoking - A report from the collaborative study on the genetics of alcoholism
    Bierut, LJ
    Dinwiddie, SH
    Begleiter, H
    Crowe, RR
    Hesselbrock, V
    Nurnberger, JI
    Porjesz, B
    Schuckit, MA
    Reich, T
    [J]. ARCHIVES OF GENERAL PSYCHIATRY, 1998, 55 (11) : 982 - 988
12345678910