Epithelial stem cells, wound healing and cancer

被引：342
作者：
Arwert, Esther N. [1 ]
Hoste, Esther [1 ]
Watt, Fiona M. [1 ]
机构：
[1] Li Ka Shing Ctr, Canc Res UK, Cambridge Res Inst, Cambridge CB2 ORE, England
来源：
NATURE REVIEWS CANCER | 2012年 / 12卷 / 03期
基金：
英国医学研究理事会; 英国惠康基金;
关键词：
GROWTH-FACTOR-ALPHA; GROUP BOX 1; HAIR FOLLICLE; BETA-CATENIN; TGF-BETA; BONE-MARROW; TRANSGENIC MICE; IN-VIVO; SONIC-HEDGEHOG; SKIN TUMOR;
D O I：
10.1038/nrc3217
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
It is well established that tissue repair depends on stem cells and that chronic wounds predispose to tumour formation. However, the association between stem cells, wound healing and cancer is poorly understood. Lineage tracing has now shown how stem cells are mobilized to repair skin wounds and how they contribute to skin tumour development. The signalling pathways, including WNT and Hedgehog, that control stem cell behaviour during wound healing are also implicated in tumour formation. Furthermore, tumorigenesis and wound repair both depend on communication between epithelial cells, mesenchymal cells and bone marrow-derived cells. These studies suggest ways to harness stem cells for wound repair while minimizing cancer risk.
引用
收藏
页码：170 / 180
页数：11
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