Epithelial stem cells, wound healing and cancer

被引：342
作者：
Arwert, Esther N. [1 ]
Hoste, Esther [1 ]
Watt, Fiona M. [1 ]
机构：
[1] Li Ka Shing Ctr, Canc Res UK, Cambridge Res Inst, Cambridge CB2 ORE, England
来源：
NATURE REVIEWS CANCER | 2012年 / 12卷 / 03期
基金：
英国医学研究理事会; 英国惠康基金;
关键词：
GROWTH-FACTOR-ALPHA; GROUP BOX 1; HAIR FOLLICLE; BETA-CATENIN; TGF-BETA; BONE-MARROW; TRANSGENIC MICE; IN-VIVO; SONIC-HEDGEHOG; SKIN TUMOR;
D O I：
10.1038/nrc3217
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
It is well established that tissue repair depends on stem cells and that chronic wounds predispose to tumour formation. However, the association between stem cells, wound healing and cancer is poorly understood. Lineage tracing has now shown how stem cells are mobilized to repair skin wounds and how they contribute to skin tumour development. The signalling pathways, including WNT and Hedgehog, that control stem cell behaviour during wound healing are also implicated in tumour formation. Furthermore, tumorigenesis and wound repair both depend on communication between epithelial cells, mesenchymal cells and bone marrow-derived cells. These studies suggest ways to harness stem cells for wound repair while minimizing cancer risk.
引用
收藏
页码：170 / 180
页数：11
相关论文
共 150 条
  • [1] Adult epidermal Notch activity induces dermal accumulation of T cells and neural crest derivatives through upregulation of jagged 1
    Ambler, Carrie A.
    Watt, Fiona M.
    [J]. DEVELOPMENT, 2010, 137 (21): : 3569 - 3579
  • [2] FcRγ Activation Regulates Inflammation-Associated Squamous Carcinogenesis
    Andreu, Pauline
    Johansson, Magnus
    Affara, Nesrine I.
    Pucci, Ferdinando
    Tan, Tingting
    Junankar, Simon
    Korets, Lidiya
    Lam, Julia
    Tawfik, David
    DeNardo, David G.
    Naldini, Luigi
    de Visser, Karin E.
    De Palma, Michele
    Coussens, Lisa M.
    [J]. CANCER CELL, 2010, 17 (02) : 121 - 134
  • [3] Upregulation of CD26 expression in epithelial cells and stromal cells during wound-induced skin tumour formation
    Arwert, E. N.
    Mentink, R. A.
    Driskell, R. R.
    Hoste, E.
    Goldie, S. J.
    Quist, S.
    Watt, F. M.
    [J]. ONCOGENE, 2012, 31 (08) : 992 - 1000
  • [4] Tumor formation initiated by nondividing epidermal cells via an inflammatory infiltrate
    Arwert, Esther N.
    Lal, Rohit
    Quist, Sven
    Rosewell, Ian
    van Rooijen, Nico
    Watt, Fiona M.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (46) : 19903 - 19908
  • [5] ASSOIAN RK, 1983, J BIOL CHEM, V258, P7155
  • [6] Ultraviolet radiation mutagenesis of hedgehog pathway genes in basal cell carcinomas
    Aszterbaum, M
    Beech, J
    Epstein, EH
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS, 1999, 4 (01) : 41 - 45
  • [7] SKIN HYPERKERATOSIS AND PAPILLOMA FORMATION IN TRANSGENIC MICE EXPRESSING A RAS ONCOGENE FROM A SUPRABASAL KERATIN PROMOTER
    BAILLEUL, B
    SURANI, MA
    WHITE, S
    BARTON, SC
    BROWN, K
    BLESSING, M
    JORCANO, J
    BALMAIN, A
    [J]. CELL, 1990, 62 (04) : 697 - 708
  • [8] Differential sensitivity of epidermal cell subpopulations to β-catenin-induced ectopic hair follicle formation
    Baker, Christopher M.
    Verstuyf, Annemieke
    Jensen, Kim B.
    Watt, Fiona M.
    [J]. DEVELOPMENTAL BIOLOGY, 2010, 343 (1-2) : 40 - 50
  • [9] Cancer as a complex genetic trait: Tumor susceptibility in humans and mouse models
    Balmain, A
    [J]. CELL, 2002, 108 (02) : 145 - 152
  • [10] The Role of Vascular Endothelial Growth Factor in Wound Healing
    Bao, Philip
    Kodra, Arber
    Tomic-Canic, Marjana
    Golinko, Michael S.
    Ehrlich, H. Paul
    Brem, Harold
    [J]. JOURNAL OF SURGICAL RESEARCH, 2009, 153 (02) : 347 - 358
12345678910