Amyloid precursor protein mRNAs in Alzheimer's disease

被引：11

作者：

Harrison, PJ

WightonBenn, WH

Heffernan, JM

Sanders, MW

Pearson, RCA

机构：

[1] UNIV OXFORD, DEPT PSYCHIAT, OXFORD OX1 2JD, ENGLAND

[2] UNIV OXFORD, DEPT CLIN NEUROL NEUROPATHOL, OXFORD OX1 2JD, ENGLAND

[3] UNIV SHEFFIELD, DEPT BIOMED SCI, SHEFFIELD S10 2TN, S YORKSHIRE, ENGLAND

[4] UNIV SHEFFIELD, DEPT PSYCHIAT, SHEFFIELD S10 2TN, S YORKSHIRE, ENGLAND

来源：

NEURODEGENERATION | 1996年 / 5卷 / 04期

基金：

英国惠康基金;

关键词：

beta-amyloid; dementia; gene expression; human brain; in situ hybridization; messenger RNA;

D O I：

10.1006/neur.1996.0055

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Hybridization studies of mRNA link genetic with neurochemical and neuropathological approaches to Alzheimer's disease (AD). Here we review the distribution and abundance of amyloid precursor protein mRNAs in normal and AD-afflicted brains. The expression of apolipoprotein E and presenilin mRNAs are also discussed. (C) 1996 Academic Press Limited

引用

页码：409 / 415

页数：7

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