Targeting dendritic cells through gold nanoparticles: A review on the cellular uptake and subsequent immunological properties

被引：74
|
作者：
Ahmad, Suhana [1 ]
Zamry, Anes Ateqah [1 ]
Tan, Hern-Tze Tina [1 ]
Wong, Kah Keng [1 ]
Lim, JitKang [2 ]
Mohamud, Rohimah [1 ]
机构：
[1] Univ Sains Malaysia, Sch Med Sci, Dept Immunol, Kelantan 16150, Malaysia
[2] Univ Sains Malaysia, Sch Chem Engn, Engn Campus Seri Ampangan, Nibong Tebal 14300, Pulau Pinang, Malaysia
来源：
MOLECULAR IMMUNOLOGY | 2017年 / 91卷
关键词：
Gold nanoparticles; Dendritic cells; Maturation; T cells; Cytokine; SURFACE-PLASMON RESONANCE; IN-VITRO; T-CELLS; HEPATOCELLULAR-CARCINOMA; COLLOIDAL STABILITY; PARTICLE-SIZE; STEADY-STATE; PHASE-I; CYTOTOXICITY; RESPONSES;
D O I：
10.1016/j.molimm.2017.09.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Gold nanoparticles (NPs) have been proposed as a highly potential tool in immunotherapies due to its advantageous properties including customizable size and shapes, surface functionality and biocompatibility. Dendritic cells (DCs), the sentinels of immune response, have been of interest to be manipulated by using gold NPs for targeted delivery of immunotherapeutic agent. Researches done especially in human DCs showed a variation of gold NPs effects on cellular uptake and internalization, DC maturation and subsequent T cells priming as well as cytotoxicity. In this review, we describe the synthesis and physiochemical properties of gold NPs as well as the importance of gold NPs in immunotherapies through their actions on human DCs.
引用
收藏
页码：123 / 133
页数：11
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