SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME NEW 1,3,4-OXADIAZOLES

被引：0

作者：

Godhani, D. R. ^{[1
]}

Dobariya, P. B. ^{[1
]}

Sanghani, A. M. ^{[1
]}

机构：

[1] Bhavnagar Univ, DST FIST Sponsored, Dept Chem, Bhavnagar 364022, Gujarat, India

来源：

INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2012年 / 21卷 / 03期

关键词：

DERIVATIVES;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of 2-((4-acetyl-5-(aryl)-5-methyl-4,5-dihydro-1,3,4-oxadiazol-2-yl) methylthio)-3-o-tolylquinazolin-4(3H)-one 5 was synthesized by the cyclization of imines 4 using acetic anhydride. The Schiff's base 4 are obtained by the reaction of appropriate carbonyl compound with 2-(4-oxo-3-o-tolyl-3,4-dihydroquinazolin-2-ylthio) acetohydrazide 3. The products are characterized by spectral and analytical data. The synthesized compounds 5a-h were screened for their antibacterial and antifungal activity.

引用

页码：259 / 262

页数：4

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