SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME NEW 1,3,4-OXADIAZOLES

被引：0
|
作者：
Godhani, D. R. [1 ]
Dobariya, P. B. [1 ]
Sanghani, A. M. [1 ]
机构：
[1] Bhavnagar Univ, DST FIST Sponsored, Dept Chem, Bhavnagar 364022, Gujarat, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2012年 / 21卷 / 03期
关键词：
DERIVATIVES;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of 2-((4-acetyl-5-(aryl)-5-methyl-4,5-dihydro-1,3,4-oxadiazol-2-yl) methylthio)-3-o-tolylquinazolin-4(3H)-one 5 was synthesized by the cyclization of imines 4 using acetic anhydride. The Schiff's base 4 are obtained by the reaction of appropriate carbonyl compound with 2-(4-oxo-3-o-tolyl-3,4-dihydroquinazolin-2-ylthio) acetohydrazide 3. The products are characterized by spectral and analytical data. The synthesized compounds 5a-h were screened for their antibacterial and antifungal activity.
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页码：259 / 262
页数：4
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