A facile transformation of alkynes into α-amino ketones by an N-bromosuccinimide-mediated one-pot strategy

被引：6

作者：

Wei, Ting ^{[1
]}

Zeng, Yongming ^{[1
,2
]}

He, Wei ^{[1
]}

Geng, Lili ^{[1
]}

Hong, Liang ^{[1
]}

机构：

[1] Changji Univ, Dept Chem & Appl Chem, Changji 831100, Peoples R China

[2] Nanjing Univ, State Key Lab Coordinat Chem, Nanjing 210093, Jiangsu, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2019年 / 30卷 / 02期

关键词：

alpha-Amino ketones; N-Bromosuccinimide; Alkynes; One-pot synthesis; HIGHLY EFFICIENT SYNTHESIS; C-H AMINATION; METHYLENEDIOXYPYROVALERONE MDPV; COMBINATION; ALCOHOLS; DOPAMINE; BASE; HYDROGENATION; TRANSPORTER; IMIDATION;

D O I：

10.1016/j.cclet.2018.03.031

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A facile transformation of alkynes into alpha-amino ketones by an N-bromosuccinimide-mediated one-pot cascade strategy is described. A variety of alpha-amino ketones are obtained in moderate to good yields under mild conditions. To overcome the multi-step synthesis, N-bromosuccinimide is involved in multiple tasks, playing a key role in the reaction course. (C) 2018 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

引用

页码：383 / 385

页数：3

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