A facile transformation of alkynes into α-amino ketones by an N-bromosuccinimide-mediated one-pot strategy

被引：6
作者：
Wei, Ting [1 ]
Zeng, Yongming [1 ,2 ]
He, Wei [1 ]
Geng, Lili [1 ]
Hong, Liang [1 ]
机构：
[1] Changji Univ, Dept Chem & Appl Chem, Changji 831100, Peoples R China
[2] Nanjing Univ, State Key Lab Coordinat Chem, Nanjing 210093, Jiangsu, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2019年 / 30卷 / 02期
关键词：
alpha-Amino ketones; N-Bromosuccinimide; Alkynes; One-pot synthesis; HIGHLY EFFICIENT SYNTHESIS; C-H AMINATION; METHYLENEDIOXYPYROVALERONE MDPV; COMBINATION; ALCOHOLS; DOPAMINE; BASE; HYDROGENATION; TRANSPORTER; IMIDATION;
D O I：
10.1016/j.cclet.2018.03.031
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A facile transformation of alkynes into alpha-amino ketones by an N-bromosuccinimide-mediated one-pot cascade strategy is described. A variety of alpha-amino ketones are obtained in moderate to good yields under mild conditions. To overcome the multi-step synthesis, N-bromosuccinimide is involved in multiple tasks, playing a key role in the reaction course. (C) 2018 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：383 / 385
页数：3
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