Actin polymerization: Where the WASP stings

被引：54

作者：

Bi, EF ^{[1
]}

Zigmond, SH

机构：

[1] Univ Penn, Sch Med, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Dept Biol, Philadelphia, PA 19104 USA

来源：

CURRENT BIOLOGY | 1999年 / 9卷 / 05期

关键词：

D O I：

10.1016/S0960-9822(99)80102-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

How do extracellular signals induce actin polymerization, as required for many cellular responses? Key signal transducers, such as the small GTPases Cdc42 and Pac have now been shown to link via proteins of the WASP family to the Arp2/3 complex, which nucleates actin polymerization. (C) Elsevier Science Ltd ISSN 0960-9822.

引用

页码：R160 / R163

页数：4

共 17 条

[1] CDC42 AND CDC43, 2 ADDITIONAL GENES INVOLVED IN BUDDING AND THE ESTABLISHMENT OF CELL POLARITY IN THE YEAST SACCHAROMYCES-CEREVISIAE [J].

ADAMS, AEM ;

JOHNSON, DI ;

LONGNECKER, RM ;

SLOAT, BF ;

PRINGLE, JR .

JOURNAL OF CELL BIOLOGY, 1990, 111 (01) :131-142

[2] SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development [J].

Bear, JE ;

Rawls, JF ;

Saxe, CL .

JOURNAL OF CELL BIOLOGY, 1998, 142 (05) :1325-1335

[3] Assembly and function of the actin cytoskeleton of yeast: Relationships between cables and patches [J].

Karpova, TS ;

McNally, JG ;

Moltz, SL ;

Cooper, JA .

JOURNAL OF CELL BIOLOGY, 1998, 142 (06) :1501-1517

[4] In vitro reconstitution of cortical actin assembly sites in budding yeast [J].

Lechler, T ;

Li, R .

JOURNAL OF CELL BIOLOGY, 1997, 138 (01) :95-103

[5] Bee1, a yeast protein with homology to Wiscott-Aldrich syndrome protein, is critical for the assembly of cortical actin cytoskeleton [J].

Li, R .

JOURNAL OF CELL BIOLOGY, 1997, 136 (03) :649-658

[6] Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex [J].

Machesky, LM ;

Insall, RH .

CURRENT BIOLOGY, 1998, 8 (25) :1347-1356

[7]

MADANIA A, 1997, YEAST, V13, pS144

[8] WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac [J].

Miki, H ;

Suetsugu, S ;

Takenawa, T .

EMBO JOURNAL, 1998, 17 (23) :6932-6941

[9] Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP [J].

Miki, H ;

Sasaki, T ;

Takai, Y ;

Takenawa, T .

NATURE, 1998, 391 (6662) :93-96

[10] The Saccharomyces cerevisiae actin-related protein arp2 is involved in the actin cytoskeleton [J].

Moreau, V ;

Madania, A ;

Martin, RP ;

Winsor, B .

JOURNAL OF CELL BIOLOGY, 1996, 134 (01) :117-132

← 1 2 →