Migraine in cervical artery dissection and ischemic stroke patients

被引：71

作者：

Metso, T. M. ^{[1
]}

Tatlisumak, T. ^{[1
]}

Debette, S. ^{[2
,3
,4
]}

Dallongeville, J. ^{[2
]}

Engelter, S. T. ^{[5
]}

Lyrer, P. A. ^{[5
]}

Thijs, V. ^{[6
]}

Bersano, A. ^{[7
]}

Abboud, S. ^{[8
]}

Leys, D. ^{[3
]}

Grond-Ginsbach, C. ^{[9
]}

Kloss, M. ^{[9
]}

Touze, E. ^{[10
]}

Pezzini, A. ^{[11
]}

Metso, A. J. ^{[1
]}

机构：

[1] Univ Helsinki, Cent Hosp, Dept Neurol, Helsinki, Finland

[2] Univ Lille Nord France, Inst Pasteur, INSERM, Dept Epidemiol & Publ Hlth,U744, Lille, France

[3] Lille Univ Hosp, Dept Neurol, EA2691, EA1046, Lille, France

[4] Univ Versailles St Quentin En Yvelines, Dept Epidemiol, Paris Ile de France Ouest Sch Med, Versailles, France

[5] Univ Basel Hosp, Dept Neurol, Basel, Switzerland

[6] VIB, Vesalius Res Ctr, Louvain, Belgium

[7] Fdn IRCCS Osped Maggiore Policlin, UO Neurol, Milan, Italy

[8] Lab Expt Neurol ULB, Brussels, Belgium

[9] Univ Heidelberg Hosp, Dept Neurol, Heidelberg, Germany

[10] Univ Paris 05, Hop St Anne, Dept Neurol, INSERM,UMS S894, Paris, France

[11] Univ Brescia, Neurol Clin, Dept Med & Surg Sci, I-25121 Brescia, Italy

来源：

NEUROLOGY | 2012年 / 78卷 / 16期

关键词：

PATENT FORAMEN OVALE; RISK-FACTORS; YOUNG-ADULTS; AGED; 15; AURA; CLASSIFICATION; METAANALYSIS; REGISTRY; SUBTYPE;

D O I：

10.1212/WNL.0b013e318251595f

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: Several small to medium-sized studies indicated a link between cervical artery dissection (CeAD) and migraine. Migrainous CeAD patients were suggested to have different clinical characteristics compared to nonmigraine CeAD patients. We tested these hypotheses in the large Cervical Artery Dissection and Ischemic Stroke Patients (CADISP) population. Methods: A total of 968 CeAD patients and 653 patients with an ischemic stroke of a cause other than CeAD (non-CeAD IS) were recruited. CeAD patients with stroke (CeAD(stroke), n = 635) were compared with non-CeAD IS patients regarding migraine, clinical characteristics, and outcome. CeAD patients with and without migraine were compared in terms of clinical characteristics and outcome. Results: Migraine was more common among CeAD(stroke) patients compared to non-CeAD IS patients (35.7 vs 27.4%, p = 0.003). The difference was mainly due to migraine without aura (20.2 vs 11.2%, p < 0.001). There were no differences in prevalence of strokes, arterial distribution, or other clinical or prognostic features between migrainous and nonmigrainous CeAD patients. Conclusion: Migraine without aura is more common among CeAD(stroke) patients compared to non-CeAD IS patients. The mechanisms and possible causative link remain to be proved. Although CeAD is often complicated by stroke, our data do not support increased risk of stroke in migrainous CeAD patients. Neurology (R) 2012;78:1221-1228

引用

页码：1221 / 1228

页数：8

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