Tuberculosis Pathogenesis and Immunity

被引：283

作者：

Philips, Jennifer A. ^{[1
]}

Ernst, Joel D.

机构：

[1] NYU, Sch Med, Dept Med, Div Infect Dis, New York, NY 10016 USA

来源：

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 7 | 2012年 / 7卷

关键词：

Mycobacterium tuberculosis; granuloma; phagosome maturation; innate immunity; acquired immunity; immune evasion; BACILLUS-CALMETTE-GUERIN; VIRULENT MYCOBACTERIUM-TUBERCULOSIS; PHAGOSOME MATURATION ARREST; HUMAN DENDRITIC CELLS; TOLL-LIKE RECEPTORS; CD8(+) T-CELLS; VITAMIN-D; IFN-GAMMA; ANTIMICROBIAL ACTIVITY; ADAPTIVE IMMUNITY;

D O I：

10.1146/annurev-pathol-011811-132458

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Despite the development of potentially curative chemotherapy, tuberculosis (TB) continues to cause increasing worldwide morbidity and is a leading cause of human mortality in the developing world. Recent advances in bacterial molecular genetics, immunology, and human genetics have yielded insight into the molecular determinants of virulence, the immune responses that are essential for restricting progressive disease, and the determinants of immunopathology in TB. Despite these advances, a large knowledge gap still exists that limits the development and testing of new interventions, including novel drugs and efficacious vaccines. This review focuses on our current knowledge of TB pathogenesis and immunity that has been derived from in vitro and in vivo studies. In addition, it highlights topics that need to be better understood to provide improved means of controlling TB worldwide.

引用

页码：353 / 384

页数：32

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