Coffee consumption and risk of endometrial cancer: a pooled analysis of individual participant data in the Epidemiology of Endometrial Cancer Consortium (E2C2)

被引：12

作者：

Crous-Bou, Marta ^{[1
,2
]}

Du, Mengmeng ^{[3
]}

Gunter, Marc J. ^{[4
]}

Setiawan, Veronica W. ^{[5
]}

Schouten, Leo J. ^{[6
]}

Shu, Xiao-ou ^{[7
]}

Wentzensen, Nicolas ^{[8
]}

Bertrand, Kimberly A. ^{[9
,10
]}

Cook, Linda S. ^{[11
,12
]}

Friedenreich, Christine M. ^{[13
,14
]}

Gapstur, Susan M. ^{[15
]}

Goodman, Marc T. ^{[16
]}

Ibiebele, Torukiri I. ^{[17
]}

La Vecchia, Carlo ^{[18
]}

Levi, Fabio ^{[19
]}

Liao, Linda M. ^{[8
]}

Negri, Eva ^{[18
,20
]}

McCann, Susan E. ^{[21
]}

O'Connell, Kelly ^{[3
]}

Palmer, Julie R. ^{[9
,10
]}

Patel, Alpa, V ^{[15
]}

Ponte, Jeanette ^{[3
]}

Reynolds, Peggy ^{[21
]}

Sacerdote, Carlotta ^{[22
]}

Sinha, Rashmi ^{[8
]}

Spurdle, Amanda B. ^{[23
]}

Trabert, Britton ^{[8
,24
,25
]}

van den Brandt, Piet A. ^{[6
]}

Webb, Penelope M. ^{[17
]}

Petruzella, Stacey ^{[3
]}

Olson, Sara H. ^{[3
]}

De Vivo, Immaculata ^{[2
,26
,27
]}

机构：

[1] Bellvitge Biomed Res Inst IDIBELL, Catalan Inst Oncol ICO, Canc Epidemiol Res Program, Unit Nutr & Canc, Barcelona, Spain

[2] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[3] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, 1275 York Ave, New York, NY 10021 USA

[4] Int Agcy Res Canc, Nutr & Metab Branch, Lyon, France

[5] Univ Southern Calif, Keck Sch Med, Dept Med, Los Angeles, CA 90007 USA

[6] Maastricht Univ, GROW Sch Oncol & Dev Biol, Dept Epidemiol, Maastricht, Netherlands

[7] Vanderbilt Univ, Med Ctr, Dept Med, Div Epidemiol,Vanderbilt Epidemiol Ctr, Nashville, TN USA

[8] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA

[9] Boston Univ, Slone Epidemiol Ctr, Boston, MA 02215 USA

[10] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA

[11] Univ New Mexico, NM Hlth Sci Ctr, Dept Internal Med, Albuquerque, NM 87131 USA

[12] Univ Calgary, Cumming Sch Med, Dept Community Hlth Sci, Calgary, AB, Canada

[13] Alberta Hlth Serv, Dept Canc Epidemiol & Prevent Res, Calgary, AB, Canada

[14] Univ Calgary, Cumming Sch Med, Dept Oncol, Calgary, AB, Canada

[15] Amer Canc Soc, Dept Populat Sci, Atlanta, GA 30329 USA

[16] Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Los Angeles, CA 90048 USA

[17] QIMR Berghofer Med Res Inst, Dept Populat Hlth, Brisbane, Qld, Australia

[18] Univ Milan, Dept Clin Sci & Community Hlth DISCCO, Milan, Italy

[19] Univ Lausanne, Ctr Primary Care & Publ Hlth Unisante, Dept Epidemiol & Hlth Serv Res, Lausanne, Switzerland

[20] Pegaso Online Univ, Dept Humanities, Naples, Italy

[21] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA

[22] Univ Hosp City Sci & Hlth, Ctr Canc Prevent CPO Peimonte, Unit Canc Epidemiol, Turin, Italy

[23] QIMR Berghofer Med Res Inst, Dept Genet & Computat Biol, Brisbane, Qld, Australia

[24] Univ Utah, Dept Obstet & Gynecol, Salt Lake City, UT USA

[25] Univ Utah, Huntsman Canc Inst, Canc Control & Populat Sci, Salt Lake City, UT USA

[26] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA

[27] Harvard Med Sch, Boston, MA 02115 USA

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 2022年 / 116卷 / 05期

基金：

英国医学研究理事会; 加拿大健康研究院; 澳大利亚国家健康与医学研究理事会; 瑞士国家科学基金会;

关键词：

coffee consumption; risk factors; endometrial cancer; pooled analysis; epidemiology; CAFFEINE INTAKE; C-PEPTIDE; PROSPECTIVE COHORT; TEA CONSUMPTION; NURSES HEALTH; ASSOCIATION; PREMENOPAUSAL; COMPONENTS;

D O I：

10.1093/ajcn/nqac229

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background: Epidemiologic studies suggest that coffee consumption may be inversely associated with risk of endometrial cancer (EC), the most common gynecological malignancy in developed countries. Furthermore, coffee consumption may lower circulating concentrations of estrogen and insulin, hormones implicated in endometrial carcinogenesis. Antioxidants and other chemopreventive compounds in coffee may have anticarcinogenic effects. Based on available meta-analyses. the World Cancer Research Fund (WCRF) concluded that consumption of coffee probably protects against EC. Objectives: Our main aim was to examine the association between coffee consumption and EC risk by combining individual-level data in a pooled analysis. We also sought to evaluate potential effect modification by other risk factors for EC. Methods: We combined individual-level data from 19 epidemiologic studies (6 cohort, 13 case-control) of 12,159 EC cases and 27,479 controls from the Epidemiology of Endometrial Cancer Consortium (E2C2). Logistic regression was used to calculate ORs and their corresponding 95% Cls. All models were adjusted for potential confounders including age. race, BMI. smoking status, diabetes status, study design. and study site. Results: Coffee drinkers had a lower risk of EC than non-coffee drinkers (multiadjusted OR: 0.87; 95% CI: 0.79. 0.95). There was a dose-response relation between higher coffee consumption and lower risk of EC: compared with non-coffee drinkers, the adjusted pooled ORs for those who drank 1, 2-3, and >4 cups/d were 0.90 (95% CI: 0.82, 1.00). 0.86 (95% CI: 0.78, 0.95), and 0.76 (95% CI: 0.66, 0.87), respectively (P-trend < 0.001). The inverse association between coffee consumption and liC risk was stronger in participants with BMI > 25 kg/m(2). Conclusions: The results of the largest analysis to date pooling individual-level data further support the potentially beneficial health effects of coffee constunption in relation to EC, especially among females with higher BMI.

引用

页码：1219 / 1228

页数：10

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