Anti-venom potential of butanolic extract of Eclipta prostrata against Malayan pit viper venom

被引：58

作者：

Pithayanukul, P ^{[1
]}

Laovachirasuwan, S

Bavovada, R

Pakmanee, N

Suttisri, R

机构：

[1] Mahidol Univ, Fac Pharm, Bangkok 10700, Thailand

[2] Chulalongkorn Univ, Fac Pharmaceut Sci, Bangkok 10330, Thailand

[3] Thai Red Cross Soc, Queen Saovabha Mem Inst, Bangkok, Thailand

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2004年 / 90卷 / 2-3期

关键词：

Eclipta prostrata; demethylwedelolactone; Calloselasma rhodostoma; Malayan pit viper; anti-snake venom;

D O I：

10.1016/j.jep.2003.10.014

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The butanolic and purified butanolic extracts (PBEs) of Eclipta prostrata were evaluated for their anti-venom potential. Inhibition of lethal, hemorrhagic, proteolytic, and phospholipase A(2) activities of Calloselasma rhodostoma (Malayan pit viper (MPV)) venom by these extracts were determined. Demethylwedelolactone was identified as their major constituent. The butanolic extract, at 2.5 mg per mouse, was able to completely neutralize the lethal activity of 2LD(50) of MPV venom, but increasing the dose diminished the effect. The PBE, at 1.5-4.5 mg per mouse, was able to neutralize the lethality of the venom at around 50-58%. Both extracts partially inhibited the hemorrhagic activity but displayed very low anti-phospholipase A(2) activity and did not inhibit proteolytic activity of MPV venom. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：347 / 352

页数：6

共 22 条

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