The global circulation of seasonal influenza A (H3N2) viruses

被引：558

作者：

Russell, Colin A. ^{[1
]}

Jones, Terry C. ^{[1
,2
,3
]}

Barr, Ian G. ^{[4
]}

Cox, Nancy J. ^{[5
]}

Garten, Rebecca J. ^{[5
]}

Gregory, Vicky ^{[7
]}

Gust, Ian D. ^{[4
]}

Hampson, Alan W. ^{[4
]}

Hay, Alan J.

Hurt, Aeron C. ^{[4
]}

de Jong, Jan C.

Kelso, Anne ^{[4
]}

Klimov, Alexander I. ^{[5
]}

Kageyama, Tsutomu

Komadina, Naomi ^{[4
]}

Lapedes, Alan S. ^{[8
]}

Lin, Yi P. ^{[7
]}

Mosterin, Ana ^{[1
]}

Obuchi, Masatsugu ^{[6
]}

Odagiri, Takato ^{[6
]}

Osterhaus, Albert D. M. E. ^{[2
]}

Rimmelzwaan, Guus F. ^{[2
]}

Shaw, Michael W. ^{[5
]}

Skepner, Eugene ^{[1
]}

Stohr, Klaus ^{[9
]}

Tashiro, Masato ^{[6
]}

Fouchier, Ron A. M. ^{[2
]}

Smith, Derek J. ^{[1
,2
]}

机构：

[1] Univ Cambridge, Dept Zool, Cambridge, England

[2] Erasmus MC, Dept Virol, Rotterdam, Netherlands

[3] Univ Pompeu Fabra, Barcelona, Spain

[4] WHO, Collaborating Ctr Reference & Res Influenza, Melbourne, Vic, Australia

[5] Ctr Dis Control & Prevent, WHO Collaborating Ctr Influenza, Atlanta, GA USA

[6] Natl Inst Med Res, WHO Collaborating Ctr Influenza, London NW7 1AA, England

[7] Natl Inst Infect Dis, WHO Collaborating Ctr Influenza, Tokyo, Japan

[8] Los Alamos Natl Lab, Div Theoret, Los Alamos, NM USA

[9] Novartis Vaccines & Diagnost, Cambridge, MA USA

来源：

SCIENCE | 2008年 / 320卷 / 5874期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1126/science.1154137

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Antigenic and genetic analysis of the hemagglutinin of similar to 13,000 human influenza A ( H3N2) viruses from six continents during 2002- 2007 revealed that there was continuous circulation in east and Southeast Asia ( E- SE Asia) via a region- wide network of temporally overlapping epidemics and that epidemics in the temperate regions were seeded from this network each year. Seed strains generally first reached Oceania, North America, and Europe, and later South America. This evidence suggests that once A ( H3N2) viruses leave E- SE Asia, they are unlikely to contribute to long- term viral evolution. If the trends observed during this period are an accurate representation of overall patterns of spread, then the antigenic characteristics of A ( H3N2) viruses outside E- SE Asia may be forecast each year based on surveillance within E- SE Asia, with consequent improvements to vaccine strain selection.

引用

页码：340 / 346

页数：7

共 33 条

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