A locus for radiation-induced gastroschisis on mouse Chromosome 7

被引：31

作者：

Hillebrandt, S

Streffer, C

Montagutelli, X

Balling, R

机构：

[1] Univ Essen Gesamthsch Klinikum, Inst Med Strahlenbiol, D-45122 Essen, Germany

[2] Inst Pasteur, Unite Genet Mammiferes, F-75724 Paris 15, France

[3] GSF Forschungszentrum Umwelt & Gesundheit, Inst Saugetiergenet, D-85764 Neuherberg, Germany

来源：

MAMMALIAN GENOME | 1998年 / 9卷 / 12期

关键词：

D O I：

10.1007/s003359900913

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gastroschisis (abdominal wall defects) occurs with a high frequency in the mouse inbred strain HLG compared with C57BL/6J mice. The risk of gastroschisis increases significantly after exposure to irradiation with X-rays during preimplantation development and follows a recessive mode of inheritance for the HLG susceptibility alleles. We have used a backcross strategy and genome-wide microsatellite typing to chromosomally map this trait. A suggestive linkage for a locus responsible for radiation-induced gastroschisis (Rigs1) was found in a region of mouse Chromosome 7.

引用

页码：995 / 997

页数：3

共 20 条

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