Prostate cancer and metastasis initiating stem cells

被引：43
|
作者：
Kelly, Kathleen [1 ]
Yin, Juan Juan [1 ]
机构：
[1] NCI, Cell & Canc Biol Branch, Ctr Canc Res, Bethesda, MD 20892 USA
来源：
CELL RESEARCH | 2008年 / 18卷 / 05期
关键词：
prostate cancer; metastasis; stem; progenitor; androgen; hedgehog;
D O I：
10.1038/cr.2008.50
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Androgen refractory prostate cancer metastasis is a major clinical challenge. Mechanism-based approaches to treating prostate cancer metastasis require an understanding of the developmental origin of the metastasis-initiating cell. Properties of prostate cancer metastases such as plasticity with respect to differentiated phenotype and androgen independence are consistent with the transformation of a prostate epithelial progenitor or stem cell leading to metastasis. This review focuses upon current evidence and concepts addressing the identification and properties of normal prostate stem or progenitor cells and their transformed counterparts.
引用
收藏
页码：528 / 537
页数：10
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