Contribution of Method of Conception on Pregnancy Outcome after the 11-13 Weeks Scan

被引:24
作者
Chaveeva, Petya [1 ]
Carbone, Ilma F. [1 ]
Syngelaki, Argyro [1 ]
Akolekar, Ranjit [1 ]
Nicolaides, Kypros H. [1 ,2 ,3 ]
机构
[1] Kings Coll Hosp London, Harris Birthright Res Ctr Fetal Med, London SE5 9RS, England
[2] Medway Maritime Hosp, Dept Fetal Med, Gillingham, England
[3] Univ Coll Hosp, Dept Fetal Med, London, England
关键词
Ovulation induction; In vitro fertilization; First-trimester screening; Miscarriage; Stillbirth; Pre-eclampsia; Gestational diabetes mellitus; Preterm delivery; Birth weight; Caesarean section; IN-VITRO FERTILIZATION; ASSISTED REPRODUCTIVE TECHNOLOGY; SINGLETON PREGNANCIES; HYPERTENSIVE DISORDERS; INCREASED RISK; CHILDREN BORN; PLACENTAL BED; BIRTH-WEIGHT; IVF; ABNORMALITIES;
D O I
10.1159/000323921
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To examine the effect of method of conception on adverse pregnancy outcome after the 11-13 weeks scan. Methods: Prospective screening study for adverse obstetric outcomes in women with singleton pregnancies and live fetus with no obvious defects at 11(+0)-13(+6) weeks. The method of conception was recorded as spontaneous, in vitro fertilization (IVF) and assisted by ovulation induction (OI) drugs without IVF. Regression analysis was performed to examine the association between the method of conception and pregnancy outcome after adjustment for maternal characteristics. Results: In the study population of 41,577 pregnancies, conception was spontaneous in 40,261 (96.9%), by IVF in 634 (1.5%) and by OI in 682 (1.6%). In the pregnancies conceived by assisted reproductive technology, compared to spontaneous conceptions, there was a higher risk of stillbirth, pre-eclampsia, gestational hypertension, gestational diabetes mellitus, delivery of small for gestational age neonates and caesarean section. However, multiple regression analysis showed that after taking into account maternal characteristics, the only significant contributions of IVF were for pre-eclampsia and elective caesarean section and the contributions of OI were for miscarriage, spontaneous early preterm delivery and small for gestational age. Conclusions: Conception by IVF and OI is associated with increased risk for adverse pregnancy outcome. Copyright (C) 2011 S. Karger AG, Basel
引用
收藏
页码:9 / 22
页数:14
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