The renaissance of natural products as drug candidates

被引:431
作者
Paterson, I [1 ]
Anderson, EA [1 ]
机构
[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England
关键词
D O I
10.1126/science.1116364
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
[No abstract available]
引用
收藏
页码:451 / 453
页数:3
相关论文
共 15 条
[1]   TOTAL SYNTHESIS OF HALICHONDRIN-B AND NORHALICHONDRIN-B [J].
AICHER, TD ;
BUSZEK, KR ;
FANG, FG ;
FORSYTH, CJ ;
JUNG, SH ;
KISHI, Y ;
MATELICH, MC ;
SCOLA, PM ;
SPERO, DM ;
YOON, SK .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (08) :3162-3164
[2]   Emergence of diverse biochemical activities in evolutionarily conserved structural scaffolds of proteins [J].
Anantharaman, V ;
Aravind, L ;
Koonin, EV .
CURRENT OPINION IN CHEMICAL BIOLOGY, 2003, 7 (01) :12-20
[3]   A planning strategy for diversity-oriented synthesis [J].
Burke, MD ;
Schreiber, SL .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (01) :46-58
[4]  
Butler MS, 2005, NAT PROD REP, V22, P162, DOI 10.1039/b402985m
[5]   A convergent enantioselective route to structurally diverse 6-deoxytetracycline antibiotics [J].
Charest, MG ;
Lerner, CD ;
Brubaker, JD ;
Siege, DR ;
Myers, AG .
SCIENCE, 2005, 308 (5720) :395-398
[6]   The evolving role of natural products in drug discovery [J].
Koehn, FE ;
Carter, GT .
NATURE REVIEWS DRUG DISCOVERY, 2005, 4 (03) :206-220
[7]   Large-scale synthesis of the anti-cancer marine natural product (+)-discodermolide.: Part 5:: Linkage of fragments C1-6 and C7-24 and finale [J].
Mickel, SJ ;
Niederer, D ;
Daeffler, R ;
Osmani, A ;
Kuesters, E ;
Schmid, E ;
Schaer, K ;
Gamboni, R ;
Chen, WC ;
Loeser, E ;
Kinder, FR ;
Konigsberger, K ;
Prasad, K ;
Ramsey, TM ;
Repic, J ;
Wang, RM ;
Florence, G ;
Lyothier, I ;
Paterson, I .
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2004, 8 (01) :122-130
[8]   Natural products as sources of new drugs over the period 1981-2002 [J].
Newman, DJ ;
Cragg, GM ;
Snader, KM .
JOURNAL OF NATURAL PRODUCTS, 2003, 66 (07) :1022-1037
[9]   Discovery of potent cell migration inhibitors through total synthesis: Lessons from structure-activity studies of (+)-migrastatin [J].
Njardarson, JT ;
Gaul, C ;
Shan, D ;
Huang, XY ;
Danishefsky, SJ .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (04) :1038-1040
[10]   The development of a practical total synthesis of discodermolide, a promising microtubule-stabilizing anticancer agent [J].
Paterson, I ;
Florence, GJ .
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2003, 2003 (12) :2193-2208