Fecal immunochemical tests-what are the advantages compared to the guaiac-based fecal occult blood test?

被引：0
作者：
Brenner, H. [1 ,2 ,3 ]
Gies, A. [2 ,4 ]
机构：
[1] Deutsch Krebsforschungszentrum DKFZ, Abt Klin Epidemiol & Alternsforsch, Neuenheimer Feld 581, D-69120 Heidelberg, Germany
[2] Deutsch Krebsforschungszentrum DKFZ, Abt Pravent Onkol, NCT, Heidelberg, Germany
[3] Deutsch Krebsforschungszentrum DKFZ, DKTK, Heidelberg, Germany
[4] Heidelberg Univ, Med Fak Heidelberg, Heidelberg, Germany
来源：
GASTROENTEROLOGE | 2019年 / 14卷 / 01期
关键词：
Colorectal cancer; Secondary prevention; Occult blood; Screening; Immunologic test; COLORECTAL-CANCER; COST-EFFECTIVENESS; DIAGNOSTIC PERFORMANCE; POPULATION;
D O I：
10.1007/s11377-018-0290-5
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
BackgroundIn 2017, the guaiac-based fecal occult blood test (gFOBT) which had been offered for colorectal cancer (CRC) screening since 1977 was replaced by fecal immunochemical tests (FITs) for hemoglobin in the German healthcare system.ObjectivesThis article aims to summarize evidence on the advantages of FITs over gFOBT in CRC screening.Materials and methodsResults of key studies from the international literature are summarized.ResultsFITs have higher sensitivity to detect CRC and its precursors than gFOBT. They specifically detect human hemoglobin in stool. Therefore, they are not influenced by dietary factors and do not require dietary restrictions. Only asingle fecal sample from one single bowel movement is required. User-friendly application is accompanied by higher adherence rates.ConclusionsBased on accumulating evidence, FITs are meanwhile widely recommended, besides screening colonoscopy, as the preferred noninvasive method for CRC screening.
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页码：6 / 13
页数：8
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