Tumor necrosis factor-α in temporomandibular joint synovial fluid predicts treatment effects on pain by intra-articular glucocorticoid treatment

被引：31

作者：

Fredriksson, Lars ^{[1
]}

Alstergren, Per ^{[1
]}

Kopp, Sigvard ^{[1
]}

机构：

[1] Karolinska Inst, Inst Odontol, Dept Clin Oral Physiol, S-14104 Huddinge, Sweden

来源：

MEDIATORS OF INFLAMMATION | 2006年 / 2006卷

关键词：

D O I：

10.1155/MI/2006/59425

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The aim of this study was to investigate the influence of tumor necrosis factor-alpha (TNF-alpha) in temporomandibular joint (TMJ) synovial fluid and blood on the treatment effect on TMJ pain by intra-articular injection of glucocorticoid in patients with chronic inflammatory TMJ disorders. High pretreatment level of TNF-alpha in the synovial fluid was associated with a decrease of TNF-alpha and elimination of pain upon maximal mouth opening. Elimination of this TMJ pain was accordingly associated with decrease in synovial fluid level of TNF-alpha. There was also a significant decrease of C-reactive protein and TMJ resting pain after treatment. In conclusion, this study indicates that presence of TNF-alpha in the synovial fluid predicts a treatment effect of intra-articular injection of glucocorticoid on TMJ movement pain in patients with chronic TMJ inflammatory disorders. Copyright (C) 2006.

引用

页数：7

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