Antibacterial Activity and DNA Binding Properties of Bivalent Metal Complexes of Cuminaldehyde Acetoylhydrazone

被引：1

作者：

Nagamani, Y. B. ^{[2
]}

Reddy, K. Hussain ^{[1
]}

Srinivasulu, K. ^{[1
]}

Dhanalakshmi, D. ^{[1
]}

Anuja, K. ^{[1
]}

机构：

[1] Sri Krishnadevaraya Univ, Dept Chem, Ananthapuramu 515003, India

[2] Govt Degree Coll W, Dept Chem, Hindupur 515201, India

来源：

ORIENTAL JOURNAL OF CHEMISTRY | 2021年 / 37卷 / 05期

关键词：

New metallo-hydrazones; Spectral characterization; DNA binding constants; Antibacterial activity; NUCLEASE ACTIVITY; LANTHANIDE(III) COMPLEXES; SPECTRAL CHARACTERIZATION; HYDRAZONE DERIVATIVES; BIOLOGICAL EVALUATION; COPPER(II) COMPLEXES; CRYSTAL-STRUCTURE; CLEAVAGE; SERIES;

D O I：

10.13005/ojc/370516

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metallo-hydrazones having the formula [M(IBAH)(2)] (where, M = Ni(II), Cu(II) and Zn(II); IBAH is p-Isopropylbenzaldehyde acetoylhydrazone) are prepared and confirmed on the basis of physicochemical and spectral analyses. Conductivity data revealed that the complexes are non-electrolytes. Metal-DNA interactions are investigated using absorption spectrophotometry. Binding constant (K-b) data revealed that the copper complex interact DNA more strongly than other complexes. Antibacterial activity studies indicated higher activity for complexes than the metal free hydrazone ligand. The copper compound displays higher activity. DNA binding constants are correlated with the activity of metal compounds in this article.

引用

页码：1125 / 1131

页数：7

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