Splicing factor SC35 promotes tau expression through stabilization of its mRNA

被引：21

作者：

Qian, Wei ^{[1
,2
]}

Iqbal, Khalid ^{[1
]}

Grundke-Iqbal, Inge ^{[1
]}

Gong, Cheng-Xin ^{[1
]}

Liu, Fei ^{[1
,2
]}

机构：

[1] New York State Inst Basic Res Dev Disabil, Dept Neurochem, Staten Isl, NY 10314 USA

[2] Nantong Univ, Jiangsu Key Lab Neuroregenerat, Jiangsu 226001, Peoples R China

来源：

FEBS LETTERS | 2011年 / 585卷 / 06期

基金：

中国国家自然科学基金; 美国国家卫生研究院;

关键词：

Tau; Alzheimer's disease; SC35; mRNA stabilization; ALZHEIMERS-DISEASE; PROTEIN-TAU; SR PROTEINS; MOUSE MODEL; PHOSPHORYLATION; TAUOPATHIES; SEQUENCES; BRAIN; TRANSLATION; GSK-3-BETA;

D O I：

10.1016/j.febslet.2011.02.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Altered alternative splicing and accumulation of brain microtubule-associated protein tau are found in several tauopathies and are believed to lead to these neurodegenerative diseases. We found that in addition to promoting tau exon 10 inclusion, splicing factor SC35 also promoted tau expression in HEK-293T cells. The activity of SC35 in promotion of tau expression was limited to exon 10 containing tau isoforms. SC35 did not affect tau transcription, but stabilized tau mRNA by binding to the SC35-like element of exon 10. These results provide novel insight into the regulation of tau expression and a molecular mechanism of tauopathies. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：875 / 880

页数：6

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