T cell metabolism in metabolic disease-associated autoimmunity

被引：13

作者：

Amersfoort, Jacob ^{[1
]}

Kuiper, Johan ^{[1
]}

机构：

[1] Leiden Univ, Div Biopharmaceut, LACDR, Einsteinweg 55, NL-2333 CC Leiden, Netherlands

来源：

IMMUNOBIOLOGY | 2017年 / 222卷 / 10期

关键词：

T cells; Cellular metabolism; Autophagy; Diabetes; Dyslipidemia; Therapeutics; ACTIVATED PROTEIN-KINASE; COENZYME-A REDUCTASE; FATTY-ACID SYNTHESIS; REGULATORY T; GLUTAMINE-METABOLISM; SIGNALING PATHWAY; MAMMALIAN TARGET; RAPAMYCIN TREATMENT; AEROBIC GLYCOLYSIS; GLYCOGEN-SYNTHASE;

D O I：

10.1016/j.imbio.2017.03.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This review discusses the relevant metabolic pathways and their regulators which show potential for T cell metabolism-based"immunotherapy in diseases hallmarked by both metabolic disease and autoimmunity. Multiple therapeutic approaches using existing pharmaceuticals are possible from a rationale in which T cell metabolism forms the hub in dampening the T cell component of autoimmunity in metabolic diseases. Future research into the effects of a metabolically aberrant micro-environment on T cell metabolism and its potential as a therapeutic target for immunomodulation could lead to novel treatment strategies for metabolic disease-associated autoimmunity. (C) 2017 The Authors. Published by Elsevier GmbH.

引用

页码：925 / 936

页数：12

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