Development of Ga-68 radiolabeled DOTA functionalized and acetylated PAMAM dendrimer-coated iron oxide nanoparticles as PET/MR dual-modal imaging agent

被引：16

作者：

Almasi, Tinoosh ^{[1
]}

Gholipour, Nazila ^{[2
,3
]}

Akhlaghi, Mehdi ^{[4
]}

Mokhtari Kheirabadi, Amin ^{[4
]}

Mazidi, Seyed Mohammad ^{[5
]}

Hosseini, Seyed Hassan ^{[6
]}

Geramifar, Parham ^{[4
]}

Beiki, Davood ^{[4
]}

Rostampour, Nima ^{[1
]}

Shahbazi Gahrouei, Daryoush ^{[7
]}

机构：

[1] Kermanshah Univ Med Sci, Sch Med, Dept Radiol, Kermanshah, Iran

[2] Baqiyatallah Univ Med Sci, Syst Biol & Poisonings Inst, Chem Injuries Res Ctr, Tehran, Iran

[3] Baqiyatallah Univ Med Sci, Fac Pharm, Tehran, Iran

[4] Univ Tehran Med Sci, Res Ctr Nucl Med, Tehran, Iran

[5] Nucl Sci & Technol Res Inst NSTRI, Radiat Applicat Res Sch, Tehran, Iran

[6] Univ Sci & Technol Mazandaran, Dept Chem Engn, Behshahr, Iran

[7] Isfahan Univ Med Sci, Sch Med, Dept Med Phys, Esfahan, Iran

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2021年 / 70卷 / 15期

基金：

美国国家科学基金会;

关键词：

Gallium-68; iron oxide nanoparticles; PET; MR imaging agent; poly(amidoamide) dendrimer; radiolabeling; MAGNETIC NANOPARTICLES; BIODISTRIBUTION; CYTOTOXICITY; CLEARANCE; OPTIMIZATION; STRATEGIES; DIAGNOSIS; TOXICITY; CONTRAST; COMPLEX;

D O I：

10.1080/00914037.2020.1785451

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Gallium-68 radiolabeled DOTA- acetyl-PAMAM coated iron oxide nanoparticles (NPs) were developed as dual-modality agents for PET-MR imaging. The increase in the chelator content, acetylation step, and radiolabeling condition had distinctive effects on the physical, biological, and radiochemical properties of NPs. The r2 relaxivity coefficient value of the NPs was 96.7 mM(-1)s(-1). High accumulation of candidate NPs was in the liver and spleen and about 3.4% ID/g uptake (tissue sampling), and a distinctive uptake (PET-CT image) were observed in the tumor site. These NPs could be used as the dual-modality agent for the diagnosis of the tumors via PET-MR imaging.

引用

页码：1077 / 1089

页数：13

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