Discrepancy in the Frequency of Y Chromosome Microdeletions Among Iranian Infertile Men with Azoospermia and Severe Oligozoospermia

被引：8
作者：
Saliminejad, Kioomars [2 ]
Sadeghi, Mohammad Reza [3 ]
Kamali, Koorosh [2 ]
Amirjannati, Naser [4 ]
Soltanghoraee, Haleh [4 ]
Khorshid, Hamid Reza Khorram [1 ]
机构：
[1] Univ Social Welf & Rehabil Sci, Genet Res Ctr, Tehran 1985713834, Iran
[2] ACECR, Avicenna Res Inst, Reprod Biotechnol Res Ctr, Tehran, Iran
[3] ACECR, Avicenna Res Inst, Monoclonal Antibody Res Ctr, Tehran, Iran
[4] Avicenna Res Inst, Avicenna Infertil Clin, Tehran, Iran
来源：
GENETIC TESTING AND MOLECULAR BIOMARKERS | 2012年 / 16卷 / 08期
关键词：
SPERMATOGENIC FAILURE; MOLECULAR DIAGNOSIS; DELETIONS; GUIDELINES; REGION; GENES; YQ11;
D O I：
10.1089/gtmb.2011.0378
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Aim: There are discrepancies in the reported frequency of Y chromosome microdeletions among Iranian infertile men. The objective of this study was to determine the frequency of Y chromosome microdeletions in an Iranian population with azoospermia and severe oligozoospermia. Methods: Totally, 94 azoospermic and 21 severe oligozoospermic patients were screened for the presence of Y chromosome microdeletions. One hundred and five fertile men were included as a control group, as well. The screening of Yq microdeletions was performed by two multiplex PCRs using six STS markers. Results: No microdeletions were detected in the men with severe oligozoospermia. In the azoospermic group 2/94 (2.13%) patients showed Y chromosome microdeletions. Among them, one patient had complete deletion of the AZFc region and the other showed complete deletion of both the AZFb and AZFc regions (AZFbc). No microdeletion was identified in the AZFa region. Conclusion: The estimated frequency of Y chromosome microdeletions in the present survey was lower than that of previous reports in Iranian populations.
引用
收藏
页码：931 / 934
页数：4
相关论文
共 50 条
  • [41] Cytogenetic and molecular analysis of infertile Chinese men: karyotypic abnormalities, Y-chromosome microdeletions, and CAG and GGN repeat polymorphisms in the androgen receptor gene
    Han, T. T.
    Ran, J.
    Ding, X. P.
    Li, L. J.
    Zhang, L. Y.
    Zhang, Y. P.
    Nie, S. S.
    Chen, L.
    GENETICS AND MOLECULAR RESEARCH, 2013, 12 (03) : 2215 - 2226
  • [42] Clinical outcomes of microdissection testicular sperm extraction and intracytoplasmic sperm injection in Japanese men with Y chromosome microdeletions
    Yamaguchi, Kohei
    Ishikawa, Tomomoto
    Mizuta, Shimpei
    Takeuchi, Takumi
    Matsubayashi, Hidehiko
    Kokeguchi, Shoji
    Habara, Toshihiro
    Ichioka, Kentaro
    Ohashi, Masakazu
    Okamoto, Sumihide
    Kawamura, Toshihiro
    Kanto, Satoru
    Taniguchi, Hisanori
    Tawara, Fumiko
    Hara, Tetsuaki
    Hibi, Hatsuki
    Masuda, Hiroshi
    Matsuyama, Takehiko
    Yoshida, Hiroaki
    REPRODUCTIVE MEDICINE AND BIOLOGY, 2020, 19 (02) : 158 - 163
  • [43] Clinical, cytogenomic, and molecular characterization of isodicentric Y-chromosome and prediction of testicular sperm retrieval outcomes in azoospermic and severe oligozoospermic infertile men
    Abur, Ummet
    Gunes, Sezgin
    Hekim, Neslihan
    Akar, Omer Salih
    Altundag, Engin
    Asci, Ramazan
    JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 2022, 39 (12) : 2799 - 2810
  • [44] A RARE COMBINATION OF 45,X/46,XY MOSAICISM AND Y CHROMOSOME MICRODELETION IN AN INFERTILE MAN WITH AZOOSPERMIA
    Aydemir, H.
    Karkucak, M.
    Cimen, H. I.
    Halis, F.
    Kumsar, S.
    Sonbahar, A. E.
    Yakut, T.
    GENETIC COUNSELING, 2016, 27 (01): : 95 - 98
  • [45] Analysis of Y Chromosome Microdeletion in 1738 Infertile Men From Northeastern China
    Zhang, Yong-Sheng
    Dai, Ru-Lin
    Wang, Rui-Xue
    Zhang, Hong-Guo
    Chen, Shuang
    Liu, Rui-Zhi
    UROLOGY, 2013, 82 (03) : 584 - 588
  • [46] Current Status of Y Chromosome Microdeletions: Prevalence, Distribution, Implication and Association with Male Infertility in Indian Men-A Review
    Rao, Mandava, V
    Shah, Nidhi P.
    Raval, Rutvik J.
    Solanki, Pooja P.
    Shah, Parth S.
    Shah, Sandip C.
    JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2021, 15 (03)
  • [47] Relationship between AZFc deletions and testicular histology in infertile South Chinese men with azoospermia and severe oligospermia
    Li, Quan
    Song, Ning-Hong
    Cao, Wen-Zhou
    Shao, Qiang
    Xie, Jian-Jun
    Liu, Chao
    Wang, Ya-Min
    Shen, Hua
    SPRINGERPLUS, 2016, 5
  • [48] Copy number variation and microdeletions of the Y chromosome linked genes and loci across different categories of Indian infertile males
    Kumari, Anju
    Yadav, Sandeep Kumar
    Misro, Man Mohan
    Ahmad, Jamal
    Ali, Sher
    SCIENTIFIC REPORTS, 2015, 5
  • [49] Association of Y chromosome AZF region microdeletions with recurrent miscarriage in Iranian couples: A case-control study
    Pazoki, Nasrin
    Salehi, Mitra
    Angaji, Seyed Abdolhamid
    Abdollahpour-Alitappeh, Meghdad
    MOLECULAR GENETICS & GENOMIC MEDICINE, 2024, 12 (02):
  • [50] FertilitY Predictor-a machine learning-based web tool for the prediction of assisted reproduction outcomes in men with Y chromosome microdeletions
    Colaco, Stacy
    Narad, Priyanka
    Singh, Ajit Kumar
    Gupta, Payal
    Choudhury, Alakto
    Sengupta, Abhishek
    Modi, Deepak
    JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 2025, 42 (02) : 473 - 481
12345