Effects of vitamin D supplementation on circulating concentrations of growth factors and immune-mediators in healthy women during pregnancy

被引:16
作者
Khatiwada, Aastha [1 ]
Wolf, Bethany J. [1 ]
Mulligan, Jennifer K. [2 ,3 ]
Shary, Judy R. [3 ]
Hewison, Martin [4 ]
Baatz, John E. [3 ]
Newton, Danforth A. [3 ]
Hawrylowicz, Catherine [5 ]
Hollis, Bruce W. [3 ]
Wagner, Carol L. [3 ]
机构
[1] Med Univ South Carolina, Dept Publ Hlth Sci, Charleston, SC 29425 USA
[2] Med Univ South Carolina, Dept Otolaryngol Head & Neck Surg, Charleston, SC 29425 USA
[3] Med Univ South Carolina, Dept Pediat, Div Neonatol, Charleston, SC 29425 USA
[4] Univ Birmingham, Med Sch, Inst Metab & Syst Res, IBR Tower,Level 2, Birmingham B15 2TT, W Midlands, England
[5] Kings Coll London, Guys Hosp, Div Asthma Allergy & Lung Biol, London, England
基金
英国医学研究理事会;
关键词
MATERNAL PLASMA-LEVELS; 1,25-DIHYDROXYVITAMIN D-3; CYTOKINE PRODUCTION; INTERFERON-GAMMA; DOUBLE-BLIND; D-DEFICIENCY; PREECLAMPSIA; FREQUENCIES; PROFILES; MARKERS;
D O I
10.1038/s41390-020-0885-7
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Background For the second aim of the Kellogg Foundation grant, this double-blind RCT investigated the impact of plasma vitamin D metabolite 25-hydroxyvitamin D (25(OH)D) on plasma immune-mediators during pregnancy. We hypothesized that higher 25(OH)D concentrations would associate with reduced pro-inflammatory and increased tolerogenic immune-mediator concentrations. Methods Pregnant women enrolled at 10-14 weeks gestation were randomized to 400 or 4400 IU vitamin D-3/day. Data on health, safety, circulating 25(OH)D, and 9 immune-mediators were collected at each trimester. Associations between immune-mediators and 25(OH)D at baseline and at second and third trimesters were examined. Results Baseline TGF-beta and second and third trimesters IFN-gamma and IL-2 were associated with baseline 25(OH)D. Baseline immune-mediators were associated with immune-mediators at second and third trimesters for all immune-mediators except IL-5 and IL-10. Race was associated with baseline TGF-beta, VEGF and IL-10 and with IL-10 at second and third trimesters. Conclusions Both treatment groups had increased 25(OH)D at second and third trimesters, greatest in the 4400 IU group. Though associations between baseline 25(OH)D and baseline TGF-beta and second and third trimester IFN-gamma and IL-2 were noted, vitamin D supplementation throughout pregnancy did not impact immune-mediators at later trimesters. Supplementing with vitamin D before conception conceivably influences immune-mediator responses during pregnancy. Impact In this vitamin D supplementation clinical trial, baseline (first trimester) but not increasing plasma 25(OH)D concentration impacted select plasma immune-mediator profiles in pregnant women. Baseline 25(OH)D was associated with baseline TGF-beta and with IFN-gamma and IL-2 at second and third trimesters. Baseline IFN-gamma, CRP, TGF-beta, TNF-alpha, VEGF, IL-2, and IL-4 were associated with concentrations at second and third trimesters for respective immune-mediators; however, 25(OH)D concentration at second and third trimesters were not. Some racial differences existed in immune-mediator concentrations at baseline and at second and third trimesters. This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial. This study found that race was associated with baseline TGF-beta, VEGF, and IL-10 and with IL-10 at second and third trimesters, a novel finding that sheds light where relationships were less well defined. The results of this study suggest that vitamin D supplementation before conception or early in pregnancy, rather than during pregnancy, may be necessary to significantly impact immune-mediator response. This study sets premise for future clinical trials to evaluate the effect of vitamin D supplementation before conception or prior to pregnancy.
引用
收藏
页码:554 / 562
页数:9
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