Anti-CD45RB/Anti-TIM-1-Induced Tolerance Requires Regulatory B Cells

被引：95

作者：

Lee, K. M. ^{[1
]}

Kim, J. I. ^{[1
]}

Stott, R. ^{[1
]}

Soohoo, J. ^{[1
]}

O'Connor, M. R. ^{[1
]}

Yeh, H. ^{[1
]}

Zhao, G. ^{[1
,2
,3
]}

Eliades, P. ^{[1
]}

Fox, C. ^{[1
]}

Cheng, N. ^{[1
]}

Deng, S. ^{[1
,2
,3
]}

Markmann, J. F. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Surg, Div Transplantat,Massachusetts Gen Hosp, Boston, MA 02115 USA

[2] Sichuan Prov Peoples Hosp, Dept Surg, Chengdu, Sichuan Provinc, Peoples R China

[3] Sichuan Acad Med Sci, Chengdu, Sichuan Provinc, Peoples R China

来源：

AMERICAN JOURNAL OF TRANSPLANTATION | 2012年 / 12卷 / 08期

关键词：

Allograft; anti-CD45RB; regulatory B; TIM-1; tolerance; ANTIGEN-PRESENTING CELLS; ALLOGRAFT-REJECTION; T-CELLS; IN-VIVO; PROTEIN ANTIGENS; ISLET ALLOGRAFTS; RESPONSES; LYMPHOCYTES; IL-10; INTERLEUKIN-10;

D O I：

10.1111/j.1600-6143.2012.04055.x

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The role of B cells in transplant tolerance remains unclear. Although B-cell depletion often prolongs graft survival, sometimes it results in more rapid rejection, suggesting that B cells may have regulatory activity. We previously demonstrated that tolerance induction by anti-CD45RB antibody requires recipient B cells. Here, we show that anti-CD45RB in combination with anti-TIM-1 antibody has a synergistic effect, inducing tolerance in all recipients in a mouse islet allograft model. This effect depends on the presence of recipient B cells, requires B-cell IL-10 activity, and is antigen-specific. These data suggest the existence of a regulatory B-cell population that promotes tolerance via an IL-10-dependent pathway.

引用

页码：2072 / 2078

页数：7

共 30 条

[1] Differential role of CCR2 in islet and heart allograft rejection: Tissue specificity of chemokine/chemokine receptor function in vivo
Abdi, R
Means, TK
Ito, T
Smith, RN
Najafian, N
Jurewicz, M
Tchipachvili, V
Charo, I
Auchincloss, H
Sayegh, MH
Luster, AD
[J]. JOURNAL OF IMMUNOLOGY, 2004, 172 (02) : 767 - 775
[2] Human dendritic cell responses to lipopolysaccharide and CD40 ligation are differentially regulated by interleukin-10
Buelens, C
Verhasselt, V
DeGroote, D
Thielemans, K
Goldman, M
Willems, F
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1997, 27 (08) : 1848 - 1852
[3] Antibody-mediated organ-allograft rejection
Colvin, RB
Smith, RN
[J]. NATURE REVIEWS IMMUNOLOGY, 2005, 5 (10) : 807 - 817
[4] CONSTANT S, 1995, J IMMUNOL, V155, P3734
[5] Cutting edge: Transplant tolerance induced by anti-CD45RB requires B lymphocytes
Deng, Shaoping
Moore, Daniel J.
Huang, Xiaolun
Lian, Moh-Moh
Mohiuddin, Muhammad
Velededeoglu, Ergun
Lee, Major K., IV
Sonawane, Samsher
Kim, James
Wang, Jing
Chen, Haiying
Corfe, Steven A.
Paige, Christopher
Shlomchik, Mark
Caton, Andrew
Markmann, James F.
[J]. JOURNAL OF IMMUNOLOGY, 2007, 178 (10) : 6028 - 6032
[6] Effect of interleukin-10 on dendritic cell maturation and function
DeSmedt, T
VanMechelen, M
DeBecker, G
Urbain, J
Leo, O
Moser, M
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1997, 27 (05) : 1229 - 1235
[7] Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice
Ding, Qing
Yeung, Melissa
Camirand, Geoffrey
Zeng, Qiang
Akiba, Hisaya
Yagita, Hideo
Chalasani, Geetha
Sayegh, Mohamed H.
Najafian, Nader
Rothstein, David M.
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (09) : 3645 - 3656
[8] Novel suppressive function of transitional 2 B cells in experimental arthritis
Evans, Jamie G.
Chavez-Rueda, Karina A.
Eddaoudi, Ayad
Meyer-Bahlburg, Almut
Rawlings, David J.
Ehrenstein, Michael R.
Mauri, Claudia
[J]. JOURNAL OF IMMUNOLOGY, 2007, 178 (12) : 7868 - 7878
[9] SMALL B-CELLS AS ANTIGEN-PRESENTING CELLS IN THE INDUCTION OF TOLERANCE TO SOLUBLE-PROTEIN ANTIGENS
EYNON, EE
PARKER, DC
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 175 (01) : 131 - 138
[10] B cells regulate autoimmunity by provision of IL-10
Fillatreau, S
Sweenie, CH
McGeachy, MJ
Gray, D
Anderton, SM
[J]. NATURE IMMUNOLOGY, 2002, 3 (10) : 944 - 950

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