Large animal models: Baboons for trauma, shock, and sepsis studies

被引：26

作者：

Redl, H ^{[1
]}

Bahrami, S ^{[1
]}

机构：

[1] Ludwig Boltzmann Inst Expt & Clin Traumatol, A-1200 Vienna, Austria

来源：

SHOCK | 2005年 / 24卷

关键词：

baboons; non-human primate; shock; trauma; sepsis; endotoxin;

D O I：

10.1097/01.shk.0000191339.46777.63

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

A few limited examples of large animal models are outlined, with the main emphasis on baboon models. The baboon offers all the advantages of a large animal and is comparable with humans in nearly all physiological and immunological aspects. In addition, cross-reactivity with human therapeutic and diagnostic reagents allows testing of new species-specific therapies such as antihuman antibodies, on the one hand, and monitoring with available human analytical procedures, on the other.

引用

页码：88 / 93

页数：6

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