Galectin-3 as a novel biomarker for disease diagnosis and a target for therapy

被引：352

作者：

Dong, Rui ^{[1
,2
]}

Zhang, Min ^{[3
]}

Hu, Qunying ^{[3
]}

Zheng, Shan ^{[1
,2
]}

Soh, Andrew ^{[4
]}

Zheng, Yijie ^{[4
]}

Yuan, Hui ^{[5
]}

机构：

[1] Fudan Univ, Childrens Hosp, Dept Pediat Hepatobiliary Surg, Shanghai 200433, Peoples R China

[2] Minist Hlth, Key Lab Neonatal Dis, Shanghai 200433, Peoples R China

[3] Xizang Minzu Univ, Med Coll, Xianyang 712000, Shaanxi, Peoples R China

[4] Abbott Labs, Abbott Diagnost Div, Med Sci Affairs, Ciros Plaza,388 Nanjing West Rd, Shanghai 200032, Peoples R China

[5] Capital Med Univ, Beijing Anzhen Hosp, Dept Clin Lab, 2 Anzhen Rd, Beijing 100029, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 2018年 / 41卷 / 02期

基金：

中国国家自然科学基金;

关键词：

galectin-3; tumor biomarker; heart disease; CHRONIC HEART-FAILURE; TERM-FOLLOW-UP; PROGNOSTIC VALUE; SERUM GALECTIN-3; MYOCARDIAL FIBROSIS; SOLUBLE ST2; IMMUNOHISTOCHEMICAL EXPRESSION; CIRCULATING GALECTIN-3; CLINICAL-SIGNIFICANCE; NATRIURETIC PEPTIDE;

D O I：

10.3892/ijmm.2017.3311

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Galectin-3 is a member of the galectin family, which are beta-galactoside-binding lectins with >= 1 evolutionary conserved carbohydrate-recognition domain. It binds proteins in a carbohydrate-dependent and -independent manner. Galectin-3 is predominantly located in the cytoplasm; however, it shuttles into the nucleus and is secreted onto the cell surface and into biological fluids including serum and urine. It serves important functions in numerous biological activities including cell growth, apoptosis, pre-mRNA splicing, differentiation, transformation, angiogenesis, inflammation, fibrosis and host defense. Numerous previous studies have indicated that galectin-3 may be used as a diagnostic or prognostic biomarker for certain types of heart disease, kidney disease and cancer. With emerging evidence to support the function and application of galectin-3, the current review aims to summarize the latest literature regarding the biomarker characteristics and potential therapeutic application of galectin-3 in associated diseases.

引用

页码：599 / 614

页数：16

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