Dynamics of Parasite Clearance in Cutaneous Leishmaniasis Patients Treated with Miltefosine

被引：26

作者：

Dorlo, Thomas P. C. ^{[1
,2
]}

van Thiel, Pieter P. A. M. ^{[1
]}

Schoone, Gerard J. ^{[3
]}

Stienstra, Ymkje ^{[1
]}

van Vugt, Michele ^{[1
]}

Beijnen, Jos H. ^{[2
]}

de Vries, Peter J. ^{[1
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Div Infect Dis, NL-1105 AZ Amsterdam, Netherlands

[2] Slotervaart Hosp, Netherlands Canc Inst, Dept Pharm & Pharmacol, Amsterdam, Netherlands

[3] Royal Trop Inst, KIT Biomed Res, Parasitol Unit, NL-1105 AZ Amsterdam, Netherlands

来源：

PLOS NEGLECTED TROPICAL DISEASES | 2011年 / 5卷 / 12期

关键词：

VISCERAL LEISHMANIASIS; CLINICAL-TRIAL; QUANTIFICATION; AMPLIFICATION; SEQUENCE; PCR;

D O I：

10.1371/journal.pntd.0001436

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Parasite loads were quantified in repeated skin biopsies from lesions of 2 patients with Old-World cutaneous leishmaniasis (CL) caused by Leishmania major and L. infantum during and after treatment with miltefosine. Miltefosine induced a rapid therapeutic effect on both infections with an initial decline of parasites of similar to 1 log/week for the L. major infection. These observations illustrate the usability of quantifying parasite loads in skin lesions as a pharmacodynamic measure and quantitative descriptor of drug effect for CL supporting clinical assessment.

引用

页数：5

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